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A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Usi...

Tarazona, Jose; Cattaneo, Irene; Niemann, Lars; Pedraza-Diaz, Susana; González-Caballero, MCarmen; Alba-Gonzalez, Mercedes de; Cañas, Ana

Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more speci...


Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the ...

Gilles, Liese; Govarts, Eva; Rodriguez Martin, Laura; Andersson, Anna-Maria; Appenzeller, Brice M.R.; Barbone, Fabio; Castano, Argelia; Coertjens, Dries

Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern and to evaluate the success of chemical policies. Europe has launched the ambitious REACH program in 2007 to improve the protection of human health and the environment. In October 2020 the EU commission published...


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