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Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerat...

Morais, Inês; Medeiros, Márcia M.; de Carvalho, Maria; Morello Bullon, Judit; M. Teixeira, Sara; Maciel, Suelma; Nhantumbo, Janice; Balau, Ana

Mechanisms of malaria parasite interaction with its host red blood cell may provide potential targets for new antimalarial approaches. Pyruvate kinase deficiency has been associated with resistance to malaria in both experimental models and population studies. Two of the major pyruvate kinase deficient-cell disorders are the decrease in ATP and the increase in 2,3-biphosphoglycerate (2,3-BPG) concentration. Hig...

Date: 2022   |   Origin: Repositório Institucional da UNL
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