37 documents found, page 1 of 4
The Festivity in Honour of Our Lady of Antime in Fafe: An emerging tourist reso...
Braga, José Luís; Mota, Catarina; Brás, Sandra; Borges, IsabelThe aim of this study was to analyse the motivations of the participants of the festivity in honour of Our Lady of Antime in Fafe (located in the north of Portugal) and provide an overview of the tourism opportunities and impacts associated with the event. To this end, the study analysed the main events on the programme for the 2024 edition of this religious festivity. According to the interviews and participan...
CytoScope – Ferramentas digitais no Ensino Superior
Fernandes, Sílvia; Mota, Catarina; Silva, Regina; Silva, Regina; Fernandes, SílviaA patologia digital tem um impacto significativo no ensino em saúde. Na área da citopatologia, as ferramentas digitais permitem o acesso remoto a casos clínicos, ultrapassando a necessidade física quer das lâminas, quer do microscópio. Dada a complexidade da citopatologia não ginecológica e a falta de ferramentas adequadas para o estudo autónomo, a modernização das ferramentas pedagógicas continua a ser uma nec...
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence ...
Pedroso, Rodrigo B.; Torres, Lícia; Ventura, Lucas Araújo; Camatta, Giovanna Caliman; Mota, Catarina; Mendes, Ana Catarina; Ribeiro, FilipaRisk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-CoV-2 infection. Among the reasons for this markedly unfavorable response in the elderly, immunosenescence and inflammaging appear as major drivers of this outcome. A finding that was also notable was that hospitalized patients with se...
The Added Value of Enhanced Depth Imaging-Optical Coherence Tomography in the M...
Cunha, Bruna; Gil, Pedro; Mota, Catarina; Hipólito-Fernandes, Diogo; Magriço, AnaIntroduction: To analyze the enhanced depth imaging (EDI) - optical coherence tomography (OCT) ability to identify, measure and classify choroidal nevi, and its correlation with high-risk features. Material and Methods: Retrospective observational study of patients with choroidal nevi. Comprehensive eye examinations and multimodal imaging were performed for each nevus, including spectral domain EDI-OCT and B-sc...
Demographic Characterization, Clinical Course and Risk Factors for Mortality of...
Antunes Meireles, Pedro; Gaspar, Pedro; Parreira, Inês; Abrantes, Ana Mafalda; Dias Silva, Virgílio; Bessa, Filipe; Pais de Lacerda, AntónioIntroduction: Clinical characteristics of Portuguese inpatients with coronavirus disease 2019 (COVID-19) are scarce. We aim to describe the demographic characteristics, clinical course and outcomes of hospitalized patients with COVID-19 and to analyze risk factors for in-hospital mortality. Material and Methods: Ambispective cohort study of adult COVID-19 patients admitted to a Portuguese tertiary hospital betw...
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells ty...
Gomes, André; Farias, Guilherme B.; Dias Silva, Manuel; Laia, Joel; Trombetta, Amelia Chiara; Godinho-Santos, Ana; Rosmaninho, Pedro; Santos, Diana F.Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of ci...
Acute HIV-1 and SARS-CoV-2 infections Share Slan+ Monocyte Depletion - evidence...
Farias, Guilherme B.; Badura, Robert; Conceição, Carolina M.; Gomes, André; Godinho-Santos, Ana; Laia, Joel; Rosmaninho, Pedro; Santos, DianaMonocytes are key modulators in acute viral infections, determining both inflammation and development of specific B- and T-cell responses. Recently, these cells were shown to be associated to different SARS-CoV-2 infection outcome. However, their role in acute HIV-1 infection remains unclear. We had the opportunity to evaluate the mononuclear cell compartment in an early hyper-acute HIV-1 patient in comparison ...
Severe COVID-19 recovery is associated with timely acquisition of a myeloid cel...
Trombetta, Amelia Chiara; Farias, Guilherme B.; Gomes, André; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição, Carolina M.; Laia, JoelAfter more than one year since the COVID-19 outbreak, patients with severe disease still constitute the bottleneck of the pandemic management. Aberrant inflammatory responses, ranging from cytokine storm to immune-suppression, were described in COVID-19 and no treatment was demonstrated to change the prognosis significantly. Therefore, there is an urgent need for understanding the underlying pathogenic mechanis...
Humoral immune response of SARS-CoV-2-infected patients with cancer: influencin...
Esperança Martins, Miguel; Gonçalves, Lisa; Soares De Pinho, Inês; Gomes, Andreia; Montesinos Serrano, Marta; Blankenhaus, BirteBackground: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with cancer show worse outcomes compared with patients without cancer. The humoral immune response (HIR) of patients with cancer against SARS-CoV-2 is not well characterized. To better understand it, we conducted a serological study of hospitalized patients with cancer infected with SARS-CoV-2. Materials and methods: This...
Seroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and healthy v...
Figueiredo-Campos, Patrícia; Blankenhaus, Birte; Mota, Catarina; Gomes, Andreia; Serrano, Marta; Ariotti, Silvia; Costa, Catarina; Nunes-Cabaço, HelenaSARS-CoV-2 has emerged as a human pathogen, causing clinical signs, from fever to pneumonia—COVID-19—but may remain mild or asymptomatic. To understand the continuing spread of the virus, to detect those who are and were infected, and to follow the immune response longitudinally, reliable and robust assays for SARS-CoV-2 detection and immunological monitoring are needed. We quantified IgM, IgG, and IgA antibodi...