25 documents found, page 1 of 3
ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric ...
Oriá, Reinaldo B.; Freitas, Raul S.; Roque, Cássia R.; Nascimento, José Carlos R; Silva, Ana Paula; Malva, João O.; Guerrant, Richard L.Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of enteric infections and malnutrition is closely related to environmental-driven enteric dysfunction early in life, and such chronic inflammatory conditions may blunt the ...
Enteropathogenic Escherichia coli Infection Induces Diarrhea, Intestinal Damage...
Ledwaba, Solanka E.; Costa, Deiziane V. S.; Bolick, David T.; Giallourou, Natasa; Medeiros, Pedro H. Q. S.; Swann, Jonathan R.; Traore, Afsatou N.Enteropathogenic E. coli (EPEC) are recognized as one of the leading bacterial causes of infantile diarrhea worldwide. Weaned C57BL/6 mice pretreated with antibiotics were challenged orally with wild-type EPEC or escN mutant (lacking type 3 secretion system) to determine colonization, inflammatory responses and clinical outcomes during infection. Antibiotic disruption of intestinal microbiota enabled efficient ...
The Transition From Undernutrition to Overnutrition Under Adverse Environments ...
Leocádio, Paola Caroline L.; Lopes, Synara C.; Dias, Ronaldo P.; Alvarez-Leite, Jacqueline I.; Guerrant, Richard L.; Malva, João O.; Oriá, Reinaldo B.Nutritional transition is an important public health issue in developing countries, where switch from undernutrition to overnutrition/obesity is rapidly occurring, often within two or three generations. Such transition is related to changes in lifestyle, with people having more access to western high-caloric diets. In developing countries, settings of poverty, poor sanitation and hygiene are still common, where...
Glutamine and Alanyl-Glutamine increase RhoA expression and reduce clostridium ...
Santos, Ana Angélica Queiroz Assunção; Braga Neto, Manuel Bonfim; Oliveira, Marcelo Róseo de; Freire, Rosemayre Souza; Barros, Eduardo BedêClostridium difficile is a major cause of antibiotic-associated colitis and is associated with signicant morbidity and mortality. Glutamine (Gln) is a major fuel for the intestinal cell population. Alanyl-glutamine (Ala-Gln) is a dipeptide that is highly soluble and well tolerated. IEC-6 cells were used in the in vitro experiments. Cell morphology was evaluated by atomic force microscopy (AFM) and scanning elec...
Effect of hypoproteic and high-fat diets on hippocampal blood-brain barrier per...
Aquino, Cristhyane Costa de; Leitão, Ricardo A.; Alves, Luis Antonio de Oliveira; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F.Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...
5-Fluorouracil induces enteric neuron death and glial activation during intesti...
Costa, Deiziane V. S.; Bon-Frauches, Ana C.; Silva, Angeline M. H. P.; Lima-Júnior, Roberto C. P.; Martins, Conceição S.5-Fluorouracil (5-FU) is an anticancer agent whose main side effects include intestinal mucositis associated with intestinal motility alterations maybe due to an effect on the enteric nervous system (ENS), but the underlying mechanism remains unclear. In this report, we used an animal model to investigate the participation of the S100B/RAGE/NFκB pathway in intestinal mucositis and enteric neurotoxicity caused b...
Morbidity, mortality, and long-term consequences associated with diarrhoea from...
Khalil, Ibrahim A.; Troeger, Christopher; Rao, Puja C.; Blacker, Brigette F.; Brown, Alexandria; Brewer, Thomas G.; Colombara, Danny V.Background The protozoan Cryptosporidium is a leading cause of diarrhoea morbidity and mortality in children younger than 5 years. However , the true global burden of C ryptosporidium infection in children younger than 5 years might have been underestimated in previous quantifications because it only took account of the acute eects of diarrhoea. W e aimed to demonstrate whether there is a causal relation betwee...
Modulation of intestinal immune and barrier functions by vitamin A: implication...
Medeiros, Pedro Henrique Q. S. de; Pinto, Daniel V.; Almeida, Juliana Zani de; Rêgo, Juliana M. C.; Rodrigues, Francisco A. P.; Lima, Aldo Ângelo M.The micronutrient vitamin A refers to a group of compounds with pleiotropic effects on human health. These molecules can modulate biological functions, including development, vision, and regulation of the intestinal barrier. The consequences of vitamin A deficiency and supplementation in children from developing countries have been explored for several years. These children live in an environment that is highly...
Revisiting inbred mouse models to study the developing brain: the potential rol...
Oriá, Reinaldo B.; Malva, João O.; Foley, Patricia L.; Freitas, Raul S.; Bolick, David T.; Guerrant, Richard L.The life-long cumulative exposures (exposome) to environmental contaminants (even low-grade lead, mercury, arsenic etc.) and biological hazards (favoring enteric pathogens and altered “unhealthy” intestinal microbiota) alone or in combination are now being increasingly recognized to deleteriously influence the brain's development and potentially the way the brain copes with aging-related conditions, including n...
Revisiting Inbred Mouse Models to Study the Developing Brain: The Potential Rol...
Oriá, Reinaldo B.; Malva, João O.; Foley, Patricia L; Freitas, Raul S.; Bolick, David T.; Guerrant, Richard L.Brazilian National Council for Scientific and Technological Development [CNPq] especial visiting researcher [N◦03/2014, # 400538/2014-8; Coordination for the Improvement of Higher Education Personnel [CAPES] Procad [071/2013 # 144494]; Bill and Melinda Gates Foundation grant # OPP1137923. Portugal - CENTRO-01-0145-FEDER-000012: HealthyAgeing 2020 and CENTRO-01-0145-FEDER-000008: BrainHealth 2020.