10 documents found, page 1 of 1
Real-World Effectiveness and Safety of Glecaprevir/Pibrentasvir for the Treatme...
Vera, José; Gomes, André; Póvoas, Diana; Seixas, Diana; Maltez, Fernando; Pedroto, Isabel; Maia, Luís; Mota, Margarida; Vieira, Maria JoãoIntroduction: Information about pan-genotypic treatments for hepatitis in Portugal is scarce. We aimed to evaluate the effectiveness and safety of glecaprevir plus pibrentasvir (GLE/PIB) treatment for hepatitis C virus (HCV) infection in real-world clinical practice.Methods: An observational prospective study was implemented in six hospitals with 121 adult HCV patients who initiated treatment with GLE/PIB betwe...
Fecal microbiota transplantation in the intestinal decolonization of carbapenam...
Silva, João Carlos; Ponte, Ana; Mota, Margarida; Pinho, Rolando; Vieira, Nuno; Oliveira, Rosa; Mota-Carvalho, Nelson; Gomes, Ana Catarina; Afecto, EdgarBackground and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that ...
Fourier transform infrared (FT-IR) spectroscopy typing: a real-time analysis of...
Silva, Liliana; Rodrigues, Carla; Lira, Agostinho; Leão, Mariana; Mota, Margarida; Lopes, Paulo; Novais, Ângela; Peixe, LuísaThe spread of multidrug-resistant (MDR) Klebsiella pneumoniae in the nosocomial setting represents a big challenge to infection control teams. We have recently developed a simple spectroscopic-based method with excellent accuracy, turnaround time and cost-effectiveness (Rodrigues et al. mSystems 2020) for bacterial typing. Here, we applied our method in a real clinical context to support early identification of...
Monitorizar para regar: o caso do castanheiro (Castanea sativa)
Mota, Margarida; Pinto, Teresa; Marques, Tiago; Borges, António; Caço, João; Veiga, Vasco; Raimundo, Fernando; Gomes-Laranjo, JoséO castanheiro é uma cultura que beneficia com a rega devendo esta ser gerida de forma sustentável, do ponto de vista da racionalização do uso de recursos naturais (água) e da rentabilidade económica da exploração agrícola (custos energéticos, mão-de-obra e produtividade do souto). Dentro do âmbito dum estudo que possui como objetivos principais apurar o efeito da rega no castanheiro, otimização de um sistema de...
Study on yield values of two irrigation systems in adult chestnut trees and com...
Mota, Margarida; Pinto, Teresa; Marques, Tiago; Borges, António; Caço, João; Raimundo, Fernando; Gomes-Laranjo, JoséDifferent types of irrigation systems can be used in chestnut orchards. To understand which one grants higher yield values treatments were applied in adult trees: drip system - TI; micro-sprinkler system - SI; non-irrigated system - NI. The study covers two years in the northeast of Portugal. Irrigation was triggered every time stem water potential was lower than -1.2 MPa. The study considers costs with the equ...
O impacto da informação jornalística no mercado acionista
Figueira, João; Mota, MargaridaO presente artigo visa perceber se a informação jornalística da imprensa generalista online sobre as sociedades anónimas desportivas dos três principais clubes portugueses — Benfica, Porto e Sporting — influencia o seu comportamento em bolsa. Para tal, aplicamos o conceito de valor-notícia de Galtung & Ruge (1969) na seleção das matérias noticiosas, para depois observar se após as respetivas publicações são vis...
Antibiotic Clinic: Two Years’ Experience in Outpatient Parenteral Antimicrobial...
Rigor, Joana; Ferreira, Paula Marques; Murteira, Fábio; Figueiredo, Cristóvão; Vieira, Nuno; Oliveira, Rosa; Couto, Raquel; Mota, MargaridaIntroduction: Outpatient antimicrobial therapy programs have been in place for more than four decades. They provide safe and effective treatment for a selected group of patients while reducing costs. In Europe in general, and in Portugal in particular, these programs are still a relatively new phenomenon. The aim of this study is to describe our center’s two years’ experience with such a program (Antibiotic Cli...
Pharmacogenomics in clinical practice: example of HLA-B*5701 and abacavir hyper...
Mendes, Daniela; Vaio, Teresa; Mota, Margarida; Gonçalves, Olga; Valente, JoãoPharmacogenomics is the study of variation in the characteristics of nucleic acids relating with response to drugs. It is considered crucial to the development of individualized Medicine. Adverse reactions to drugs increase morbidity, mortality and healthcare costs. Pharmacogenomics holds the potential to reduce drugs adverse reactions. HIV infected patients have a higher incidence of hypersensitivity reactions...
Clearence of C virus after acute hepatitis B
Sousa, Marta; Correia, Margarida; Moreira, Joana; Eiras, Eduardo; Mota, Margarida; P. Dias, Vitor; Gonçalves, Manuel; Vieira, RosasIntroduction: The replication of Hepatitis B (HBV) and C (HCV) virus and the immune response involved in the mechanism of hepatic lesion in viral hepatitis remains unknown.Case report: The authors present a 34 year-old male patient, an intravenous drug addict in abstinence for 5 years, with Hepatitis C diagnosed for a year, genotype 3a. In December 2004 he had acute hepatitis B with stage 4 encephalopathy and a...
Polyarteritis nodosa - with reference to two clinical cases
Neves, Sofia; Mota, Margarida; Dias, Manuela; Relvas, Moura; Valente, JoãoPolyarteritis nodosa is a multisystemic necrotizingvasculitis of small and medium-sized arteries.Peripheral nerve, kidney, skin, gastrointestinal tract,cardiac and musculoskeletal involvement is common.The authors present two case reports with differentclinical features and treatment.; A poliarterite nodosa é uma vasculite necrosantesistémica que envolve as artérias de pequeno e médiocalibre, atingindo preferen...