21 documents found, page 1 of 3

The emerging landscape of SGLT2 inhibitors in pediatric populations with kidney...

Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i), originally developed as innovative antihyperglycemic agents, have demonstrated significant benefits in improving metabolic markers and protecting the kidneys and heart in patients with or without type 2 diabetes mellitus. The mechanisms behind these unexpected cardiorenal benefits cannot be attributed solely to improved glycemic control. Recent data s...

Pediatric kidney transplant and cardiometabolic risk: a cohort study

Abstract Introduction: Patients with chronic kidney disease (CKD) are known to have increased cardiovascular risk but there are few data on the risk of pediatric kidney transplant recipients. We aimed to assess the impact of pre- and post-transplant overweight on allograft function and to characterize the evolution of several cardiovascular risk variables over time and their impact. Methods: A retrospective ana...

Hypokalemia and hyperkalemia: Two Sides of the Same Coin

Abstract Introduction: Potassium (K+) is the main intracellular cation and is crucial for normal cellular function, especially during children’s development and growth course. Changes in the homeostatic mechanisms of potassium regulation can lead to hypokalemia or hyperkalemia. Objective: This study aimed to provide a narrative review of this common, yet complex, condition of the clinical practice. Development/...

Genetic atypical hemolytic uremic syndrome in children: a 20-year experience fr...

Abstract Introduction: Atypical hemolytic uremic syndrome (aHUS) is a rare disorder characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury, which primarily affects preschool-aged children. This study’s aim was to describe the clinical profile, management, and long-term outcome of the genetic aHUS patients admitted to a tertiary care pediatric nephrology center...

Kidney disease in tuberous sclerosis complex: A single-center experience

Introduction: Tuberous sclerosis complex is an autosomal dominant neurocutaneous disorder which is characterized by multisystem involvement, including the kidney. Since renal disease is one of the causes of morbidity and mortality, close management is essential. Subjects and Methods: In this retrospective observational,single-center study, authors analyse patients with a definite diagnosis of tuberous sclerosis...

Rituximab use in children with complicated idiopathic nephrotic syndrome - a si...

Background: In children with idiopathic nephrotic syndrome, rituximab can maintain short-term remission allowing steroids and calcineurin inhibitors taper. Methods: We retrospectively reviewed all children receiving rituximab for idiopathic nephrotic syndrome at a tertiary hospital. All patients, except one who received a single dose, had four infusions of 375mg/m2 of rituximab at a one-week interval, minimum f...

Severe hypokalemia in a child with mild gastroenteritis

Introdução: A hipocalémia (potássio sérico inferior a 3.5 mmol/L) pode ser causada por vários mecanismos. A hipocalémia grave é uma emergência médica pelas importantes repercussões cardíacas que pode ter. Caso clínico: Uma rapariga de oito anos, previamente saudável, com crescimento normal e tensão arterial tendencialmente baixa, foi observada por dor abdominal persistente, anorexia e febre dois dias após recup...

Nephro urology case

The Nutcracker Syndrome (NS) originates from the compression of the left renal vein in its trajectory, mostly between the aorta and the superior mesenteric artery, or less frequently between the aorta and the lumbar spine. Although asymptomatic in most cases, it can be a rare cause of hematuria. We present the case of an 11-year-old male adolescent who was referred to a Pediatric Nephrology evaluation for a two...

Risk Factors For Renal Scarring After First Febrile Urinary Tract Infection

Introduction: The urinary tract infection (UTI) is one of the most common paediatric infectious diseases and it increases the risk for hypertension and end-stage renal disease. Authors’ aim was to identify risk factors for permanent renal injury after a first febrile urinary tract infection. Methods: Retrospective analysis of clinical, laboratorial and imaging data of children aged 1 to 36 months hospitalized b...

O desafio do diagnóstico de uma vasculite anca positivo em idade pediátrica