54 documents found, page 1 of 6
Index of Microcirculatory Resistance in the Assessment of Coronary Microvascula...
Aguiar Rosa, S; Mota Carmo, M; Rocha Lopes, L; Oliveira, E; Thomas, B; Baquero, L; Cruz Ferreira, R; Fiarresga, AIntroduction and objectives: Coronary microvascular dysfunction (CMD) is one of the most important pathophysiological features in hypertrophic cardiomyopathy (HCM). The index of microcirculatory resistance (IMR) is an invasive method to assess the coronary microcirculation. The aim was to assess CMD in patients with HCM by IMR. Methods: Adult patients with HCM without epicardial coronary artery disease underwen...
Blunted Coronary Flow Velocity Reserve is Associated With Impairment in Systoli...
Aguiar Rosa, S; Rocha Lopes, L; Branco, L; Galrinho, A; Fiarresga, A; Thomas, B; Brás, P; Gonçalves, A; Cardoso, I; Papoila, A; Alves, M; Rio, PBackground Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (HCM). We aimed to assess the association between impaired coronary flow velocity reserve (CFVR) and ventricular systolic function and functional capacity. Methods Eighty-three patients with HCM were enrolled in this prospective cohort study. Patients underwent echocardiogram to evalu...
Associations Between Perfusion Defects, Tissue Changes and Myocardial Deformati...
Brás, P; Aguiar Rosa, S; Thomas, B; Fiarresga, A; Cardoso, I; Pereira, R; Branco, G; Cruz, I; Baquero, L; Cruz Ferreira, R; Mota Carmo, MBackground: Microvascular dysfunction is an often overlooked feature of hypertrophic cardiomyopathy (HCM). Our aim was to assess the association between microvascular dysfunction, wall thickness, tissue characteristics and myocardial deformation in HCM patients, by analyzing individual myocardial segments. Methods: Prospective assessment including cardiac magnetic resonance to assess wall thickness, T1 and T2 m...
The Impact of Ischemia Assessed by Magnetic Resonance on Functional, Arrhythmic...
Aguiar Rosa, Silvia; Thomas, Boban; Fiarresga, Antonio; Papoila, A.L.; Alves, Marta; Pereira, Ricardo; Branco, Goncalo; Cruz, Ines; Rio, PedroFunding: LL is supported by an MRC UK clinical academic partnership award (CARP) MR/T005181/1.
Association between mir-146a and tumor necrosis factor alpha (Tnf-α) in stable ...
Pereira-da-Silva, Tiago; Napoleão, Patrícia; Costa, Marina C.; Gabriel, André F.; Selas, Mafalda; Silva, Filipa; Enguita, Francisco J.Background and Objectives: Tumor necrosis factor alpha (TNF-α) is proatherogenic and associated with the risk of acute ischemic events, although the mechanisms that regulate TNF-α expression in stable coronary artery disease (SCAD) are not fully understood. We investigated whether metabolic, inflammatory, and epigenetic (microRNA (miRNA)) markers are associated with TNF-α expression in SCAD. Materials and Metho...
The Impact of Ischemia Assessed by Magnetic Resonance on Functional, Arrhythmic...
Aguiar Rosa, S; Thomas, B; Fiarresga, A; Papoila, AL; Alves, M; Pereira, R; Branco, G; Cruz, I; Rio, P; Baquero, L; Cruz Ferreira, R; Mota Carmo, MAims: The aim of the study is to investigate the association between the degree of ischemia due to coronary microvascular dysfunction (CMD) and the left ventricular (LV) tissue characteristics, systolic performance, and clinical manifestations in hypertrophic cardiomyopathy (HCM). Methods and Results: This prospective study enrolled 75 patients with HCM without obstructive epicardial coronary artery disease. Ea...
Proinflammatory Soluble CD40 Ligand Is Associated with the Systemic Extent of S...
Pereira da Silva, T; Napoleão, P; Pinheiro, T; Selas, M; Silva, F; Cruz Ferreira, R; Mota Carmo, MBackground and objectives: Polyvascular atherosclerosis is frequent and associated with a high cardiovascular risk, although the mechanisms regulating the atherosclerosis extent to single or multiple arterial territories are still poorly understood. Inflammation regulates atherogenesis and soluble CD40 ligand (sCD40L) is an inflammatory mediator associated with the presence of single-territorial atherosclerosis...
Prognostic Effect and Modulation of Cardiac Sympathetic Function in Heart Failu...
Ilhão Moreira, R; Abreu, A; Portugal, G; Oliveira, L; Oliveira, MM; Rodrigues, I; Coutinho Cruz, M; Silva Cunha, P; Santos, V; Santa Clara, HBackground: Cardiac autonomic dysfunction as assessed by 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy is associated with poor prognosis in heart failure (HF) patients. Although cardiac resynchronization therapy (CRT) has emerged as an effective therapy in improving outcomes on HF patients, its effect on cardiac sympathetic nervous function is still not fully understood. We aimed to study the value of p...
Será a síndrome metabólica um marcador de prognóstico em doentes com elevado ri...
Timóteo, Ana Teresa; Mota Carmo, M; Soares, Cristina; Cruz Ferreira, RuiIntroduction: Obese patients are at higher cardiovascular risk in primary prevention. In secondary prevention, an obesity paradox has been reported. We analyzed a cohort of individuals from a previous cross‐sectional study on the impact of metabolic syndrome (MS) on coronary artery disease (CAD), aiming to assess the occurrence of cardiovascular events in a long follow‐up. Methods: We analyzed 296 individuals i...
Has Carotid Intima-Media Thickness Prognostic Impact in Patients with High Card...
Timóteo, AT; Mota Carmo, M; Soares, C; Cruz Ferreira, RBACKGROUND: Carotid intima-media thickness (CIMT) is an established surrogate marker for cardiovascular events in patients with intermediate risk. In patients with high cardiovascular risk or established cardiovascular disease, the impact of CMIT measurement on risk stratification for future events is less clear. Our objective was to evaluate the impact of CIMT on the occurrence of cardiovascular events in a co...