Herpes simplex virus type 2 (HSV-2) is widely distributed through the human population, infecting more than 500 million people globally. Although causing generally mild infections this virus may cause severe symptoms occasionally, mainly in immunocompromised patients. Presently, there are a number of systemic antiviral agents against herpesvirus, the most commonly used being acyclovir (ACV) and its prodrugs. Ho...