35 documents found, page 1 of 4
Clinical Pharmacy Services: What We Need to Define
Castel-Branco, Maria Margarida; Mota-Filipe, Helder; Figueiredo, Isabel Vitória.
Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of ...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Šeminská, Patrícia; Valová, Katarína; Bellón, Loreto; Dias-Pereira, Patrícia; Marques, FranklimPd2Spm is a dinuclear palladium(II)-spermine chelate with promising anticancer properties against triple-negative breast cancer (TNBC), a breast carcinoma subset with poor prognosis and limited treatment options. The present study evaluated the in vitro and in vivo anticancer effects of Pd2Spm compared to the reference metal-based drug cisplatin. Triple-negative breast cancer MDA-MB-231 cells, non-cancerous MCF...
Contributions to the improvement of healthcare management for cardiovascular pa...
Campos Fernandes, Adalberto; Abreu, Ana; Pinto, Fausto J.; Mota-Filipe, Helder; Machado, Maria do Céu; Carrageta, ManuelCardiovascular disease (CVD) is among the leading causes of morbidity, disability and mortality in Portugal. Despite the considerable decline in cardiovascular mortality as a result of improved healthcare access, diagnostic testing, new pharmacological treatments and regulatory measures, such as the new tobacco law, CVD remains the number one cause of mortality in women and is second to cancer in men. It is est...
Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Batista de Carvalho, Ana L. M.Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinet...
Preclinical pharmacokinetics and biodistribution of anticancer dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Batista de Carvalho, Ana L. M.Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinet...
Primary health care policy and vision for community pharmacy and pharmacists in...
Ribeiro, Nadine; Mota-Filipe, Helder; Guerreiro, Mara P.; Costa, Filipa. A.The central role of the Portuguese National Health Service (P-NHS) guarantees virtually free universal coverage. Key policy papers, such as the National Health Plan and the National Plan for Patient Safety have implications for pharmacists, including an engagement in medicines reconciliation. These primary health care reform, while not explicitly contemplating a role for pharmacists, offer opportunities for the...
Therapeutic effects of IkB kinase inhibitor during systemic inflammation
Amaro-Leal, Ângela; Shvachiy, Liana; Pinto, Rui; Geraldes, Vera; Rocha, Isabel; Mota-Filipe, HelderAnimal models of inflammatory diseases support the idea that nuclear factor κB (NF-κB) activation plays a pathophysiological role and is widely implicated in multiple organ dysfunction (MOD). Indeed, the inhibition of the IκB kinase (IKK) complex, involved in the NF-κB pathway, can represent a promising approach to prevent MOD. The present work employed a rat model of systemic inflammation to investigate the pr...
Hemin reduces inflammation associated with TNBS-induced colitis
Mateus, Vanessa; Rocha, João; Mota-Filipe, Helder; Sepodes, Bruno; Pinto, RuiPurpose - Hemin is a heme-oxygenase inducer, which can confer anti-inflammatory, cytoprotective, and antiapoptotic effects. These properties are beneficial therapeutical effects to inflammatory bowel disease (IBD). IBD is a worldwide health problem characterized by chronic inflammation of intestinal epithelium, which promotes intestinal and extraintestinal symptomatology. Current treatment only induces and main...
Inflammation and autonomic function
Leal, Ângela; Carvalho, Mafalda; Rocha, Isabel; Mota-Filipe, HelderInflammation is generally a temporary and limited condition but may lead to a chronic one if immune and physiological homeostasis are disrupted. The autonomic nervous system has an important role in the short- and, also, long-term regulation of homeostasis and, thus, on inflammation. Autonomic modulation in acute and chronic inflammation has been implicated with a sympathetic interference in the earlier stages ...
Anti-inflammatory effect of erythropoietin in the TNBS-induced colitis
Mateus, Vanessa; Rocha, João; Alves, Paula; Mota-Filipe, Helder; Sepodes, Bruno; Pinto, Rui Manuel AmaroErythropoietin is a potent stimulator of erythroid progenitor cells, which is able to inhibit NF-kB activation, due to its pleiotropic properties, thus promoting an anti-inflammatory effect. As inflammatory bowel disease is a chronic disease with reduced quality of life, and the current pharmacotherapy only induces or maintains the patient in remission, there is a crucial need of new pharmacological approaches....