25 documents found, page 1 of 3
Epigenetic alterations in urothelial bladder cancer associated with disease out...
Martins Nunes, Francisca; Apolónio, Joana; Mota-Pinto, A; Leão, RicardoObjectives: Bladder cancer (BLCA) is a molecular heterogeneous disease with known genetic distinctive signatures. However, DNA methylation is highly prevalent across a wide range of tumors, suggesting its potential in oncogenesis. Here, we aimed to interrogate the role of nine epigenetic alterations as diagnostic and prognostic markers in BLCA.Methods: DNA methylation, gene expression, and clinicopathological i...
Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-cent...
Malva, J.; Verissimo, MT; Mota-Pinto, A; Todo-Bom, A.; MASK study groupAims Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of he...
MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis...
Malva, J.; Verissimo, MT; Mota-Pinto, A; Todo-Bom, A.; MASK study groupmHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mob...
Asthma and rhinitis have different genetic profiles for IL13, IL17A and GSTP1 p...
Resende, EP; Todo-Bom, A; Loureiro, C; Mota-Pinto, A; Oliveiros, B; Mesquita, L; Silva, HCBACKGROUND: Asthma and rhinitis have a complex etiology, depending on multiple genetic and environmental risk factors. An increasing number of susceptibility genes are currently being identified, but the majority of reported associations have not been consistently replicated across populations of different genetic backgrounds. PURPOSE: To evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A...
A Standardized Classification for Subdural Hematomas- I
Alves, JL; Santiago, JG; Costa, G; Mota-Pinto, ASubdural hematomas are a frequent and highly heterogeneous traumatic disorder, with significant clinical and socioeconomic consequences. In clinical and medicolegal practice, subdural hematomas are classified according to its apparent age, which significantly influences its intrinsic pathogenic behavior, forensic implications, clinical management, and outcome. Although practical, this empirical classification i...
The association of asthma, nasal allergies, and positive skin prick tests with ...
Newson, RB; Jones, M; Forsberg, B; Janson, C.; Bossios, A.; Dahlen, S-E; Toskala, EM; Al-Kalemji, A; Kowalski, ML; Rymarcsyk, B.; Salagean, EMBackground Cross-sectional and longitudinal reports show that obese adults have more asthma than non-obese adults. A proposed mechanism is via effects of adipokines (leptin and adiponectin) on the immune system. Objective We wished to measure the associations of asthma and other atopic diseases with serum adipokine levels and to find whether the associations with asthma were strong enough to rule out the possib...
Oxidative Stress Adaptation in Aggressive Prostate Cancer May Be Counteracted b...
Freitas, M; Baldeiras, I; Proença, T; Alves, V; Mota-Pinto, A; Sarmento-Ribeiro, AOxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HPV...
FoxP3, GATA-3 and T-bet expression in elderly asthma
Vale-Pereira, S; Todo-Bom, A; Geraldes, L; Schmidt-Weber, C; Akdis, CA; Mota-Pinto, ABACKGROUND: Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role. The transcription factor FoxP3 plays a role in Treg differentiation while T-bet is important for Th1 and GATA-3 for Th2 differentiation from naïve T cells. Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial t...
Aging and asthma - changes in CD45RA, CD29 and CD95 T cells subsets
Todo-Bom, A; Mota-Pinto, A; Alves, V; Santos-Rosa, MBACKGROUND: Aging is associated with thymus involution leading to a reduction in naive T cells and to an accumulation of effector-memory cells. Apoptosis is a key mechanism to clear the immune system from activated and harmful cells. In asthma the stimulation of T cells by environmental antigens can decrease naive cells and sustain activated cells. The aim of this work was to evaluate the imbalance between CD45...
Recommendations for assessing patient-reported outcomes and health-related qual...
Baiardini, I; Braido, F; Bindslev-Jensen, C; Bousquet, PJ; Brzoza, Z; Canonica, GW; Compalati, E; Fiocchi, A; Fokkens, W; Gerth van Wijk, RThe aim of this Global Allergy and Asthma European Network (GA(2)LEN) consensus report is to provide recommendations and suggestions for assessing patient-reported outcomes (PROs) including health-related quality of life in patients with urticaria. We recommend that PROs should be used both in clinical trials and routine practice for the evaluation of urticaria patients. We suggest that PROs should be considere...