7 documents found, page 1 of 1
Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania am...
Sampaio,Raimunda Nonata Ribeiro; Ferreira,Marina Freitas; Martins,Sofia Sales; Motta,Jorgeth de Oliveira Carneiro daAbstract Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and l...
Dramatic secukinumab-mediated improvements in refractory leprosy-related neurit...
Kurizky,Patrícia Shu; Motta,Jorgeth de Oliveira Carneiro da; Bezerra,Natanael Victor Furtunato; Sousa,Marcia Carolline dos Santos; Corazza,DaniloAbstract A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the posterior modulation of interferon- γ (IFN-γ), tumor necrosis factor- α (TNF-α,) interleukin-17A (IL-17A), and IL-12/23p40 after the induction phase of sec...
A randomized, open-label clinical trial comparing the long-term effects of milt...
Sampaio,Raimunda Nonata Ribeiro; Silva,Juliana Saboia Fontenele e; Paula,Carmen Dea Ribeiro de; Porto,Cláudia; Motta,Jorgeth de Oliveira Carneiro daAbstract INTRODUCTION: The treatment of mucosal leishmaniasis (ML) is difficult due to the toxicity and route of administration of standard drugs. Miltefosine is an oral agent used for leishmaniasis treatment; however, no data exist regarding its use for ML in Brazil. In this study, we aimed to evaluate the efficacy of miltefosine for ML treatment compared to that of pentavalent antimonial in a pilot study. MET...
Wade’s histoid leprosy in a 14-year-old teenage boy
Figueira,Renata Borges Fortes da Costa; Oliveira,Karen Fernandes de; Souza,Luciana Borges de; Takano,Gustavo Henrique SoaresAbstract Wade’s histoid leprosy (HL) is a rare variant of multibacillary leprosy, with characteristic clinical, immunologic, histopathologic, and bacteriologic features. It is associated with resistance to sulfa drugs or polychemotherapy and is rarely observed in patients who have not undergone prior treatment. Clinically, HL resembles keloid or dermatofibroma. Furthermore, HL is rare in children and is difficu...
Periungual leishmaniasis
Gomes,Ciro Martins; Morais,Orlando Oliveira de; Leite,Anglya Samara Silva; Soares,Killarney Ataíde; Motta,Jorgeth de Oliveira Carneiro daThe vast majority of cases of cutaneous leishmaniasis are represented by limb injuries. A female patient, white, presented an ulcer with infiltrated borders located on the fourth finger of the left hand following occupational exposure in an area of native forest. Diagnosis of cutaneous leishmaniasis caused by Leishmania of the subgenus Viannia was confirmed. The patient failed to respond to treatment with antim...
Ocorrência familiar de esporotricose zoonótica
Cordeiro,Fernanda Nóbrega; Bruno,Carolina Barbosa; Paula,Carmen Déa Ribeiro de; Motta,Jorgeth de Oliveira Carneiro daA esporotricose é micose subaguda ou crônica, causada pelo fungo dimórfico Sporothrix schenckii, endêmica no Brasil e transmitida principalmente através da inoculação traumática de seu agente causal na pele. A transmissão zoonótica, especialmente por gatos infectados, tem sido demonstrada em diversos relatos e séries de casos. Nós descrevemos a ocorrência simultânea da doença em três membros de uma mesma famíli...
Leishmaniose mucosa fatal em criança
Velozo,Daniela; Cabral,Andréa; Ribeiro,Maria Custódia Machado; Motta,Jorgeth de Oliveira Carneiro da; Costa,Izelda Maria CarvalhoA leishmaniose tegumentar americana, doença endêmica e crescente no Brasil, pode manifestar-se por úlceras na pele e lesões nas mucosas nasal, oral e faringiana. O antimônio pentavalente é a droga de primeira escolha no tratamento, com resposta menos favorável nas formas mucosas. Destaca-se a dificuldade para diagnosticar e tratar um caso de leishmaniose mucosa em criança de cinco anos que teve exames parasitol...