6 documents found, page 1 of 1
Protease inhibitors from marine venomous animals and their counterparts in terr...
Mourão, Caroline Barbosa Farias; Schwartz, Elisabeth Nogueira FerroniThe Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms. These inhibitors consist of a chain of ~60 amino acid residues stabilized by three disulfide bridges, and was first observed in the bovine pancreatic trypsin inhibitor (BPTI)-like protease inhibitors, which strongly inhibit trypsin and chymotrypsin. In this r...
Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscuru...
Guerrero Vargas, Jimmy Alexander; Mourão, Caroline Barbosa Farias; Quintero Hernández, Verónica; Possani, Lourival D.Background: Colombia and Brazil are affected by severe cases of scorpionism. In Colombia the most dangerous accidents are caused by Tityus pachyurus that is widely distributed around this country. In the Brazilian Amazonian region scorpion stings are a common event caused by Tityus obscurus. The main objective of this work was to perform the molecular cloning of the putative Na+-channel scorpion toxins (NaScTxs...
Nova classe de inibidor de serinopeptidase presente na peçonha do escorpião Tit...
Mourão, Caroline Barbosa FariasTese (doutorado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, Programa de Pós-Graduação em Biologia Molecular, 2016.; O interesse na caracterização de novos inibidores de peptidases (PIs) tem aumentado nas últimas décadas devido a seu potencial uso na prevenção e tratamento de diversas doenças humanas. Muitos PIs já foram caracterizados de animais venenosos e peç...
Antiviral activity of animal venom peptides and related compounds
Mata, Élida Cleyse Gomes da Mata; Mourão, Caroline Barbosa Farias; Rangel, Marisa; Schwartz, Elisabeth Nogueira FerroniViruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases...
Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscuru...
Guerrero Vargas, Jimmy Alexander; Mourão, Caroline Barbosa Farias; Quintero Hernández, Verónica; Possani, Lourival D.Background: Colombia and Brazil are affected by severe cases of scorpionism. In Colombia the most dangerous accidents are caused by Tityus pachyurus that is widely distributed around this country. In the Brazilian Amazonian region scorpion stings are a common event caused by Tityus obscurus. The main objective of this work was to perform the molecular cloning of the putative Na+-channel scorpion toxins (NaScTxs...
Prospecção de peptídeos neuroativos da peçonha caranguejeira Acanthoscurria pau...
Mourão, Caroline Barbosa FariasDissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Biologia Animal, 2012.; Aranhas produzem em sua peçonha uma complexa mistura de moléculas, as quais, devido a seus potenciais neurotoxicos, tem despertado o interesse para a prospecção de novos fármacos e pesticidas. No entanto, poucos estudos são realizados com a peçonha de aranhas caranguejeiras, em...