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Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltr...
Ignácio, Zuleide M.; Réus, Gislaine Z.; Abelaira, Helena M.; Maciel, Amanda L.; Moura, Airam B. de; Matos, Danyela; Demo, Júlia P.Stress in early life has been appointed as an important phenomenon in the onset of depression and poor response to treatment with classical antidepressants. Furthermore, childhood trauma triggers epigenetic changes, which are associated with the pathophysiology of major depressive disorder (MDD). Treat- ment with atypical antipsychotics such as quetiapine, exerts therapeutic effect for MDD patients and induces ...
Effects of ketamine administration on mTOR and reticulum stress signaling pathw...
Abelaira, Helena M.; Réus, Gislaine Z.; Ignácio, Zuleide M.; Santos, Maria Augusta B. dos; Moura, Airam B. de; Matos, Danyela; Demo, Júlia P.Recent studies show that activation of the mTOR signaling pathway is required for the rapid antide- pressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists. A relationship be- tween mTOR kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded protein response (UPR) has been shown. We evaluate the effects of ketamine administration on the mTOR signaling pathway...