12 documents found, page 1 of 2
Spectrum of Cutaneous Lesions in a Cohort of Patients With Neurofibromatosis Ty...
Fialho, Maria C; Garrido, Pedro M; Santos-Coelho, Miguel; Ferreirinha, Ana; Martins, Bárbara D; Passos, João; Moura, CecíliaBackground: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant syndrome with a predisposition to the development of central nervous system tumors, ophthalmic manifestations, and dermatological lesions. The latter are present in 70-95% of patients and can precede the evolution of other tumors. However, they are not included in the diagnostic criteria and are frequently undervalued during follow-up. Meth...
Benign Fibrous Histiocytoma of the Lung: A Case Report
Rosa, Rita; Moura, Cecília; Bravio, Ivan; Cabrera, Rafael; Rolim, Ricardo; Almodovar, Maria TeresaA fibrous histiocytoma is a benign tumoral lesion generally localized in the dermis or the superficial subcutaneous tissue. Fibrous histiocytoma of the lung is a very rare tumor, with only a few cases in the literature. We present a case of a 48-year-old man, asymptomatic, with a solitary pulmonary nodule with a high metabolism in PET/TC. Given the location and suspicious hypermetabolism in PET/TC, the patient ...
Hutchinson’s Sign in Congenital Nail Matrix Nevus
Ferreirinha, Ana; Fialho, Maria C; Garrido, Pedro M.; Costa-Rosa, Joaninha; Moura, CecíliaCongenital nail matrix nevi (NMN) are a rare cause of melanonychia that may present with irregularity, asymmetry, and multicomponent pigmentation posing diagnostic challenges with subungual melanoma. We report a case of a 49-year-old female with longitudinal melanonychia and a 1-month recent pigmentation in the proximal nail fold. This sign is traditionally associated with malignancy, which further complicates ...
Cutaneous Adverse Events of Targeted Therapies and Immune-Checkpoint Inhibitors...
Pimenta, Rita; Costa-Rosa, Joaninha; Cravo, Mariana; Rafael, Margarida; Moura, CecíliaTargeted therapy and immunotherapy have markedly improved prognosis of advanced melanoma patients. With expanded use of these drugs, a range of cutaneous adverse events has emerged. Although the vast majority of adverse events are low-grade, they many cause significant morbidity and can affect patients' quality of life. Early diagnosis and prompt intervention may prevent unnecessary discontinuation of life-savi...
Characterization of the Population with BRAF V600 Mutation in Patients with Met...
Mendonça-Sanches, Maria; Apalhão, Miguel; Vale-Fernandes, Pedro; Rito, Miguel; Costa-Rosa, Joaninha; Moura, CecíliaIntroduction: Although corresponding to only 5% of cutaneous neoplasms, melanoma is the tumor of this organ with the highest mortality rate. The constant development of new drugs, particularly those targeting the B-Raf protein, has significantly increased overall patient survival. To date, several studies have evaluated the clinical-pathological correlations with this mutation. However, no study has been publis...
Sentinel Lymph Node Biopsy in Head and Neck Cutaneous Malignant Melanoma
António, Ana Marta; Moura, Cecília; Semedo, Carina; Bitoque, Sandra; Martins, Mariluz; Vilares, Miguel; Pecegueiro, Manuela; Rosa Santos, JorgeIntroduction: Sentinel lymph node biopsy (SLNB) is the standard of care for cutaneous melanoma, including head and neck melanoma. The aim of this study was to analyze and characterize SLNB in a population of head and neck melanoma patients. Methods: A unicentric, retrospective study on patients with cutaneous head and neck melanoma who underwent SLNB in the Department of Head and Neck Surgery at the Portuguese ...
Immune Response in Melanoma: A Basis to Understand the Role of Immunotherapy wi...
Matos Pires, Eugénia; Moura, CecíliaThe knowledge of the pathophysiology of tumour progression is crucial to understand the therapeutic targets in order to control the disease. The mechanisms used by the immune system to affect cancer development and progression has been a challenging question in immunology. It is now postulated that immunology plays a dual role in this process: it protects against tumour growth, destroying “aberrant” tumour cell...
Euromelanoma in Portugal 2010-2016
Duarte, Filipa; Correia, Osvaldo; Maia e Silva, João Nuno; Moura, Cecília; Vieira, Ricardo; Picoto, AntónioIntroduction: The incidence of skin cancer has been increasing in recent years around the world. Key targets in the fight against skin cancer include alerting populations to primary prevention by promoting knowledge about risk factors and encouraging better sun protection behaviors as well as secondary prevention promoting skin self-examination and screenings. The Portuguese Society of Dermatology and Venereolo...
Immune Checkpoint Inhibitors in Melanoma: Review and Update
Matos Pires, Eugénia; Moura, CecíliaThe overall increasing incidence of melanoma will very probably be the trend over the next two decades. This data stresses the need for new therapeutic resources, other than classic chemotherapy. Nevertheless, the treatment of advanced melanoma has been changed in the last decade due to novel therapeutic strategies, including immunotherapy with immune checkpoint inhibitors targeting cytotoxic T lymphocyte-assoc...
Terapêutica Sistémica no Melanoma Avançado Systemic Therapy in Advanced Melanoma
Moura, Cecília.