5 documents found, page 1 of 1
Resistance profile of osimertinib in pre-treated patients with EGFR T790M-mutat...
Fernandes, Maria Gabriela O.; Sousa, Catarina; Jacob, Maria; Almeida, Leonor; Santos, Vanessa; Araújo, David; Bastos, Hélder Novais; Magalhães, AdrianaOsimertinib efficacy in pre-treated patients with epidermal growth factor receptor (EGFR) T790M-mutated non-small cell lung cancer (NSCLC) has been demonstrated in clinical trials, but real-world data, particularly regarding resistance profile, remains limited. This study aims to analyze the resistance mechanisms acquired after treatment with Osimertinib. Clinical outcomes and molecular results from re-biopsie...
Targeted Gene Next-Generation Sequencing Panel in Patients with Advanced Lung A...
Fernandes, Maria Gabriela O.; Jacob, Maria; Martins, Natália; Moura, Conceição Souto; Guimarães, Susana; Pereira Reis, Joana; Justino, AnaIdentification of targetable molecular changes is essential for selecting appropriate treatment in patients with advanced lung adenocarcinoma. Methods: In this study, a Sanger sequencing plus Fluorescence In Situ Hybridization (FISH) sequential approach was compared with a Next-Generation Sequencing (NGS)-based approach for the detection of actionable genomic mutations in an experimental cohort (EC) of 117 pati...
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cel...
Granja, Sara Costa; Marchiq, Ibtissam; Le Floch, Renaud; Moura, Conceição Souto; Baltazar, Fátima; Pouysségur, JacquesMost cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4). These transporters require a chaperone, CD147/BASIGIN (BSG) for trafficking to the plasma membrane and function. To validate the key role of these transporters in lung cancer, we fir...
Pneumonia intersticial descamativa em doente com conectividade indiferenciada
Bastos, Hélder Novais; Sampaio, Luzia; Mota, Patrícia; Cunha, Rui; Pardal, Joana; Moura, Conceição Souto; Morais, AntónioHomem caucasiano de 49 anos de idade, fumador (15 UMA), com quadro clínico inicial de poliartrite simétrica e aditiva, envolvendo predominantemente as pequenas articulações das mãos, punhos, ombros e tíbio-társicas. O estudo auto-imune revelou positividade para ANA e anticorpo anti-proteína P ribosómica. Foi diagnosticada conectivite indiferenciada e iniciou terapêutica com deflazacorte, naproxeno e hidroxiclor...
Whipple disease and central nervous system.
Abreu, Pedro; Azevedo, Elsa; Lobo, Luís; Moura, Conceição Souto; Pontes, CelsoWhipple disease (WD) is a rare systemic infection caused by the bacteria Tropheryma whipplei. Slowly progressive dementia, supranuclear ophthalmoplegia, headache, myoclonus, hypothalamic dysfunction, oculomasticatory-skeletal myorythmia are characteristic manifestations when WD involves the central nervous system (CNS). Treatment of cerebral WD should be performed with antibiotics that reach the CNS for at the ...