A acessibilidade é um conjunto de meios que possibilita o acesso a todos, independentemente das suas condições de mobilidade reduzida ou necessidades especiais. Se nos focarmos no acesso à informação, então poderemos invocar a “Declaração de Acessibilidade e Usabilidade Web” (Acessibilidade.gov.pt, 2018). Este estudo incide sobre a importância da acessibilidade à informação por parte de utilizadores com limitaç...
Nosocomial infections represent an ongoing challenge to healthcare quality and patient safety, negatively impacting clinical outcomes and increasing the burden on healthcare systems. Thus, controlling this type of infection plays a very important role in ensuring a better quality of life for patients. Although the control and prevention measures for these infections are well defined, their signaling and detecti...
Introduction: Methods for the automated and accurate identification of metabolites in 1D 1H-NMR samples are crucial, but this is still an unsolved problem. Most available tools are mainly focused on metabolite quantification, thus limiting the number of metabolites that can be identified. Also, most only use reference spectra obtained under the same specific conditions of the target sample, limiting the use of ...
Nanocomposites as drug delivery systems (e.g., metal nanoparticles) are being exploited for several applications in the biomedical field, from therapeutics to diagnostics. Green nanocomposites stand for nanoparticles of biocompatible, biodegradable and non-toxic profiles. When using metal nanoparticles for drug delivery, the question of how hazardous these virus-sized particles can be is posed, due to their nan...
Nanocomposites as drug delivery systems (e.g., metal nanoparticles) are being exploited for several applications in the biomedical field, from therapeutics to diagnostics. Green nanocomposites stand for nanoparticles of biocompatible, biodegradable and non-toxic profiles. When using metal nanoparticles for drug delivery, the question of how hazardous these "virus-sized particles" can be is posed, due to their n...
Introdução e objetivo(s): A produção científica de uma especialidade é um sinal de vitalidade e de autorreflexão indispensável à identidade de qualquer disciplina científica. O estudo pretende descrever a investigação original efetuada por especialistas ou internos da especialidade de medicina geral e familiar (MGF) publicada na Acta Médica Portuguesa (AMP), na Revista Portuguesa de Medicina Geral e Familiar (R...
Banana and plantain are monocotyledonous plants belonging to the genus Musa, family Musaceae, and order Zingiberales. All around the world, the importance of banana plant increases with its different applications in pharmaceutical and food industries and in other biotechnologically related processes. This chapter provides an overview of bioactive compounds in banana and biological activities of banana's seconda...
Cancer cells undergo metabolic changes that contribute to tumorigenesis, which can be determined using metabolomics data produced by techniques such as nuclear magnetic resonance and mass spectroscopy, and analyzed through statistical and machine learning methods. Since these data represent well the metabolic phenotype of these cells, they are very relevant in cancer research, to better understand tumour cells ...
The uptake of 17α-ethinylestradiol (EE2) by the green alga Ulva lactuca and its effects on the metabolome of that macroalgae have been investigated using 1H-NMR spectroscopy. To this end, U. lactuca in vitro cultures have been acutely (48 h) exposed to the estrogen and both, endo- and exometabolome were investigated. Bioinformatic analyses were performed to integrate and analyze endo- and exometabolic profiles ...
Metabolomics data analysis is an important task in biomedical research. The available tools do not provide a wide variety of methods and data types, nor ways to store and share data and results generated. Thus, we have developed WebSpecmine to overcome the aforementioned limitations. WebSpecmine is a web-based application designed to perform the analysis of metabolomics data based on spectroscopic and chromatog...