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Potent antileukemic action of naphthoquinoidal compounds : evidence for an intr...
Cavalcanti, Bruno C.; Cabral, Igor O.; Rodrigues, Felipe A. R.; Barros, Francisco W. A.; Rocha, Danilo D.; Magalhães, Hemerson I. F.; Moura, Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β- lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor ce...
Date: 2014
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Origin: Oasisbr