56 documents found, page 1 of 6

Promoting advanced medical services in the framework of 3PM-a proof-of-concept ...

Multidisciplinary team from three universities based in the "Centro" Region of Portugal developed diverse approaches as parts of a project dedicated to enhancing and expanding Predictive, Preventive, and Personalized Medicine (3PM) in the Region. In a sense, outcomes acted as a proof-of-concept, in that they demonstrated the feasibility, but also the relevance of the approaches. The accomplishments comprise def...

Stable variable selection method with shrinkage regression applied to the selec...

In this work, we aimed to establish a stable and accurate procedure with which to perform feature selection in datasets with a much higher number of predictors than individuals, as in genomewide association studies. Due to the instability of feature selection where many potential predictors are measured, a variable selection procedure is proposed that combines several replications of shrinkage regression models...

miRNAs in Heart Development and Disease

Cardiovascular diseases (CVD) are a group of disorders that affect the heart and blood vessels. They include conditions such as myocardial infarction, coronary artery disease, heart failure, arrhythmia, and congenital heart defects. CVDs are the leading cause of death worldwide. Therefore, new medical interventions that aim to prevent, treat, or manage CVDs are of prime importance. MicroRNAs (miRNAs) are small ...

Promoting advanced medical services in the framework of 3PM: a proof-of-concept...

Multidisciplinary team from three universities based in the "Centro" Region of Portugal developed diverse approaches as parts of a project dedicated to enhancing and expanding Predictive, Preventive, and Personalized Medicine (3PM) in the Region. In a sense, outcomes acted as a proof-of-concept, in that they demonstrated the feasibility, but also the relevance of the approaches. The accomplishments comprise def...

Myocardial RNA sequencing reveals new potential therapeutic targets in heart fa...

Heart failure with preserved ejection fraction (HFpEF) represents a global health challenge, with limited therapies proven to enhance patient outcomes. This makes the elucidation of disease mechanisms and the identification of novel potential therapeutic targets a priority. Here, we performed RNA sequencing on ventricular myocardial biopsies from patients with HFpEF, prospecting to discover distinctive transcri...

Sequenciação de DNA – NGS manual de boas práticas

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Genetic predisposition for low functional status in COPD

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Decoding The Genetic Architecture Behind Disease Heterogeneity: A Genome-Wide A...

Pulmonary, as well as extrapulmonary features such as muscle weakness and reduced exercise capacity, contribute signifcantly to the morbidity and mortality as well as the individual, social and economic burden of chronic obstructive pulmonary disease (COPD). Aetiology is multifactorial, including extrinsic factors such as smoking, inactivity, malnutrition and corticosteroid use, as well as intrinsic factors suc...

Assessment of the stability of a procedure for variables selection in high dime...

The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Br...

Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...