52 documents found, page 1 of 6

Addressing Critical Fungal Pathogens Under a One Health Perspective

Fungal infections have emerged as a significant public health concern, especially with the increasing incidence of severe mycoses caused by pathogens such as Aspergillus fumigatus, Candida auris, Candida albicans, and Cryptococcus neoformans. These fungi, listed as critical priorities by the World Health Organization, pose a heightened risk due to rising antifungal resistance and their severe impact on immunoco...

Promoting advanced medical services in the framework of 3PM-a proof-of-concept ...

Multidisciplinary team from three universities based in the "Centro" Region of Portugal developed diverse approaches as parts of a project dedicated to enhancing and expanding Predictive, Preventive, and Personalized Medicine (3PM) in the Region. In a sense, outcomes acted as a proof-of-concept, in that they demonstrated the feasibility, but also the relevance of the approaches. The accomplishments comprise def...

Genetic predisposition for low functional status in COPD

Sem resumo disponível.

Decoding The Genetic Architecture Behind Disease Heterogeneity: A Genome-Wide A...

Pulmonary, as well as extrapulmonary features such as muscle weakness and reduced exercise capacity, contribute signifcantly to the morbidity and mortality as well as the individual, social and economic burden of chronic obstructive pulmonary disease (COPD). Aetiology is multifactorial, including extrinsic factors such as smoking, inactivity, malnutrition and corticosteroid use, as well as intrinsic factors suc...

The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Br...

Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...

Assessment of the stability of a procedure for variables selection in high dime...

Assessment of the stability of a procedure for variables selection in high dime...

No abstract available.

The role of MicroRNAs in proteostasis decline and protein aggregation during br...

Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...

Unveiling the genome of Limtongozyma cylindracea

Association of positive and negative life events with cognitive performance and...

Objectives: Life events have important effects on psychological well-being. Yet, studies have mainly focused on exploring the impact of traumatic and negative experiences on health and well-being, with positive events receiving marginal attention. In this study, we investigated the association between negative and positive life events, cognitive performance and psychological status in older individuals. Method:...