2 documents found, page 1 of 1
Treatment and cure of HIV infection : available drugs, resistance pathways, and...
Moura, InesHuman immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) are the cause of acquired immunodeficiency syndrome (AIDS). What was once a death sentence has become a chronically manageable condition with the introduction of antiretroviral therapy (ART). Although HIV-2 infection has a much lower prevalence than HIV-1 infection, its intrinsic resistance to specific classes of antiretroviral drugs (ARVs) presents s...
High Instantaneous Inhibitory Potential of Bictegravir and the New Spiro-β-Lact...
Bártolo, Inês; Moura, Ines; Gonçalves, Paloma; Diniz, Ana Rita; Borrego, Pedro; Martin, Francisco; Figueiredo, Inês; Gomes, PerpétuaIntegrase inhibitors (INIs) are an important class of drugs for treating HIV-2 infection,given the limited number of drugs active against this virus. While the clinical efficacy of raltegravirand dolutegravir is well established, the clinical efficacy of bictegravir for treating HIV-2 infected patients has not been determined. Little information is available regarding the activity of bictegravir against HIV-2 i...