16 documents found, page 1 of 2

Phosphatases in Mitosis: Roles and regulation

Mitosis requires extensive rearrangement of cellular architecture and of subcellular structures so that replicated chromosomes can bind correctly to spindle microtubules and segregate towards opposite poles. This process originates two new daughter nuclei with equal genetic content and relies on highly-dynamic and tightly regulated phosphorylation of numerous cell cycle proteins. A burst in protein phosphorylat...

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Che...

Faithfull genome partitioning during cell division relies on the Spindle Assembly Checkpoint (SAC), a conserved signaling pathway that delays anaphase onset until all chromosomes are attached to spindle microtubules. Mps1 kinase is an upstream SAC regulator that promotes the assembly of an anaphase inhibitor through a sequential multi-target phosphorylation cascade. Thus, the SAC is highly responsive to Mps1, w...

First-Episode Psychosis in a 15 Year-Old Female with Clinical Presentation of A...

Anti-NMDA receptor encephalitis is an autoimmune disease that was identified in 2007, and manifests in a stepwise manner with psychiatric, neurological and autonomic symptoms. The disease is caused by autoantibodies against NMDA receptors. It can have a paraneoplastic origin, mainly secondary to ovarian teratomas, but it can also be unrelated to the tumor. This disease can affect both sexes and all ages. CASE P...

First-episode psychosis in a 15 year-old female with clinical presentation of a...

BACKGROUND: Anti-NMDA receptor encephalitis is an autoimmune disease that was identified in 2007, and manifests in a stepwise manner with psychiatric, neurological and autonomic symptoms. The disease is caused by autoantibodies against NMDA receptors. It can have a paraneoplastic origin, mainly secondary to ovarian teratomas, but it can also be unrelated to the tumor. This disease can affect both sexes and all ...

Ontem, hoje e amanhã O Trabalho da Equipa de Pedopsiquiatria do Hospital de Vil...

Nova PPP e Nova Psiquiatria

Reabilitação de Reimplantação do Antebraço Distal Pós-Amputação - a Propósito d...

Actualmente, o desafio da reimplantação do membro superior pós-amputação tornou-se uma realidade alcançável e minuciosamente aperfeiçoada nas últimas décadas, e em permanente evolução. A opção cirúrgica de reimplantação deve ter em conta não apenas a análise exclusiva da viabilidade do reimplante, mas, fundamentalmente o seu potencial de recuperação funcional a longo prazo. Apresenta-se o caso clínico de um jov...

Psychiatry training towards a global future: trainees' perspective in Portugal

Introduction: Psychiatry is influenced by society changes, so it should be permanently updating itself, foreseeing future behaviours and pathologies. This study aims to describe psychiatry trainee’s opinion in Portugal concerning their training and the modifications they would want to witness in the near future. Material and Methods: A structured questionnaire of 26 questions was developed by the Portuguese Ass...

Por Detrás do Sintoma : Um Caso de POC na Infância

Transformação cavernosa da veia porta

Introdução: na transformação cavernosa da veia portal (TCVP) as opções terapêuticas são escassas mas em casos seleccionados a construção de shunt fisiológico meso-Rex (SMR) é uma opção. Caso Clínico 1: Rapariga de 13 anos de idade, com síndrome polimalformativo. Internamento aos 4 meses de idade na Unidade de Cuidados Intensivos por pneumonia com repercussão hemodinâmica. Aos sete anos por trombocitopénia e esp...