19 documents found, page 1 of 2
Update on the systemic management of noninfectious uveitis in children and adol...
Leal, Ines; Steeples, Laura R.; Wong, Shiao Wei; Giuffrè, Chiara; Pockar, Sasa; Sharma, Vinod; Green, Elspeth K.Y.; Payne, Janine; Jones, Nicholas P.Noninfectious uveitis (NIU) in children and adolescents is a rare but treatable cause of visual impairment in children. Treatments for pediatric NIU and their side effects, along with the risks of vision loss and the need for long-term disease monitoring, pose significant challenges for young patients and their families. Treatment includes local and systemic approaches and this review will focus on systemic the...
Design and development of a web-based prospective nationwide registry for ocula...
Leal, Ines; Nogueira, Vanda; Matos, Diogo Bernardo; Araújo, Joana; Berens, Olga; Ribeiro, Margarida; Furtado, Maria João; Liverani, MarcoUveitis is a heterogeneous collection of infrequent diseases, which poses significant challenges to cost-effective research in the field. Medical registries are being increasingly recognized as crucial tools to provide high-quality data, thus enabling prospective clinical research. This paper describes the design and technical structure development of an innovative countrywide electronic medical record for uvei...
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms a...
Kuiper, Jonas J. W.; Prinz, Jörg C.; Stratikos, Efstratios; Kuśnierczyk, Piotr; Arakawa, Akiko; Springer, Sebastian; Mintoff, Dillon; Padjen, IvanThe 'MHC-I (major histocompatibility complex class I)-opathy' concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet's disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene ...
Real‐world outcomes of adalimumab in adults with non‐infectious uveitis
Leal, Ines; Wong, Shiao Wei; Giuffre, Chiara; Patil, Ajay; Sousa, David Cordeiro; Barbosa‐Breda, João; Chhabra, Ramandeep; Jones, Nicholas P.Purpose: To present real-world adalimumab (ADA) efficacy and safety outcomes in non-infectious uveitis (NIU) from a single United Kingdom (UK) tertiary centre. Methods: Retrospective review of adult patients with NIU treated with ADA. Data were collected at baseline, 6 and 12 months. The primary goal was to evaluate the rate of treatment failure, using the VISUAL-I/II studies criteria, during 12 months of follo...
The role of biologics in non-infectious uveitis
Leal, InesNon-infectious uveitis (NIU) comprises a heterogeneous group of inflammatory diseases of the uvea and is commonly believed to result from an imune-mediated response to ocular antigens. Complications of uveitis can be sight-threatening, severely impairing quality of life (QoL). Hence, NIU brings a significant burden for both healthcare systems and affected patients, who tend to be young and professionally active...
A non-infectious uveitis multidisciplinary clinic in a tertiary referral center...
Leal, Ines; Romão, Vasco C.; Sousa Mano, Sofia; Khmelinskii, Nikita; Campanilho-Marques, Raquel; Ponte, Cristina; Macieira, CarlaNon-infectious uveitis (NIU) is a group of sight-threatening diseases that generates significant burden for the healthcare systems due to its adverse outcomes, irreversible structural complications in the eye with loss of visual function, limited clinical expertise and low-grade evidence for best practice. The usefulness of multidisciplinary care, specifically close collaboration between Rheumatologists and Oph...
Retinal vascular reactivity in type 1 diabetes patients without retinopathy usi...
Sousa, David Cordeiro; Leal, Ines; Moreira, Susana; Vale, Sónia do; Silva-Herdade, Ana S.; Aguiar, Patrício; Dionísio, Patrícia; Pinto, LuisPurpose: We hypothesize that patients with type 1 diabetes (T1D) may have abnormal retinal vascular responses before diabetic retinopathy (DR) is clinically evident. Optical coherence tomography angiography (OCTA) was used to dynamically assess the retinal microvasculature of diabetic patients with no clinically visible retinopathy. Methods: Controlled nonrandomized interventional study. The studied population ...
Tubulointerstitial nephritis and uveitis TINU syndrome : a review
Amaro, David; Carreño, Ester; Steeples, Laura R.; Oliveira Ramos, Filipa; Marques-Neves, Carlos; Leal, InesInflammation of renal interstitium and uveal tissue establishes the two components of tubulointerstitial nephritis and uveitis (TINU) syndrome. Although believed to occur more frequently in young females, a broad spectrum of patients can be affected. Both renal and eye disease can be asymptomatic and may not manifest simultaneously, having independent progressions. Renal disease manifests as acute kidney injury...
Optical coherence tomography angiography study of the retinal vascular plexuses...
Sousa, David Cordeiro; Leal, Ines; Moreira, Susana; Vale, Sónia do; Silva-Herdade, Ana S.; Dionísio, Patrícia; Castanho, Miguel A. R. B.; Pinto, LuisAim Previous data suggest the existence of retinal vascular changes and impaired autoregulation in the very early stages of diabetic retinopathy (DR). We compared the retinal plexuses between patients with type 1 diabetes (T1D) without DR and a demographically similar healthy cohort, using optical coherence tomography angiography (OCT-A). Methods Patients with T1D and no signs of DR were prospectively recruited...
Choosing Wisely Portugal : a visão dos médicos portugueses
Morgado, Mariana; Alves, Mariana; Reis-de-Carvalho, Catarina; Viegas Dias, Catarina; Sousa, David Cordeiro; Santos, Guilherme; Leal, InesEm outubro de 2018 foi apresentado o conceito e modo de implementação do programa Choosing Wisely Portugal — Escolhas Criteriosas em Saúde. Este programa tem como objetivo promover escolhas em Saúde baseadas na melhor evidência cientifica, reduzindo o número de intervenções desnecessárias, sem eficácia comprovada e/ou com uma relação risco-benefício desfavorável.1,2 A colaboração dos médicos é essencial para co...