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Crusades in the Making of the Global Early Modern World
Teixeira, André; Lázaro, AntónioThe chapter explores the ideological foundations of early Portuguese overseas expansion, emphasizing the centrality of the Crusade as a legitimizing and mobilizing framework in campaigns across North Africa and the Indian Ocean. Beginning with the conquest of Ceuta in 1415, Portuguese kings and nobles framed their expansion as a continuation of the Iberian Reconquista, embedding their actions within a broader C...
Thyroid Metastasis as the Initial Presentation of an Asymptomatic Clear Cell Re...
Carmelino, Janine; Tavares, Ana Paula; Crespo, Ana; Coutinho, José Mário; Lázaro, António; Ribeiro, Vasco; Barroso, EduardoIntroduction: Clear cell renal carcinoma metastases to the thyroid gland are rare and only diagnosable after an immunohistochemistry analysis of the histological sample. The purpose of this article is to report a case of thyroid metastasis as the initial presentation of a clear cell renal carcinoma.Case Report: Male patient with a solid nodule in the left lobe of the thyroid, 5.3 cm in diameter, suspicious of m...
COMEDONAL DARIER’S DISEASE
Mestre, Tiago; Assis Pacheco, Fernando; Lázaro, António; Cardoso, JorgeDarier disease is an autosomal dominant dermatosis caused by the mutation of the ATP2A2 gene. There are rarer clinical variants showing atypical skin lesions like the hypertrophic, vesicobollous, hypopigmented, and comedonal subtypes. We present the case of a 28-years-old healthy man with more than hundred pruritic open comedone-like hyperkeratotic dark papules of the upper and lower back. Histological examinat...
Primary solitary amyloidoma of the lumbar spine
Murinello, António; Figueiredo Coelho, J.; Mendonça, Paula; Milheiro, Adelaide; Lázaro, António; Arias, Jesus; Teiga, Carlos; Simões, JoséPrimary solitary amyloidoma of the spine is an extremely rare form of localized deposits of amyloid on bone tissue and has a predilection for the thoracic region. It arises within the bone marrow of the vertebral body, causing pain and neurologic symptoms due to bone destruction with fracture and collapse, visible on imagiologic studies as osteolytic lesions usually associated with adjacent soft tissue masses. ...
Angiosarcoma of the lower limb misdiagnosed as deep thrombophlebitis – a review
Murinello, António; Fernandes, Cândida; Neta, Jorge; Árias, Jesus; Afonso, Ana; Cabral, Vitória; Germano, Nuno; Mendonça, Paula; Ribeiro, AnalisaAngiosarcomas are very rare sarcomas with vascular differentiation, high-grade malignant behaviour, early metastasis and generally bad prognosis. Early diagnosis is very important for adequate radical ablative surgery in order to obtain a better prognosis. The authors present a case of very aggressive angiosarcoma of the leg, admitted in a very advanced stage with extensive metastases, due to an initial misdiag...