22 documents found, page 1 of 3
The impact of metal ions on the photo-antibacterial efficiency of metalloporphy...
Chaves, Inês; Morais, Filipe F. M.; Vieira, Cátia; Bartolomeu, Maria; Gomes, Ana T. P. C.; Faustino, M. Amparo F.; Neves, M. Graça P. M. S.The influence of metal ions on the photochemical, photophysical, and antibacterial properties of three cationic porphyrin-triphenylphosphonium conjugates was investigated for the first time. Coordination with Zn(II), Pd(II) and Co(II) enabled fine-tuning of these conjugates properties, with Zn(II) complexes demonstrating particular promise. While Pd(II) and Co(II) complexes failed to generate singlet oxygen (1O...
PVP formulations of bis-cyclometalated iridium(III) complexes bearing β-modifie...
Moura, Nuno M. M.; Reis, Melani J. A.; Lodeiro, Carlos; Neves, M. Graça P. M. S.; Cavaleiro, José A. S.; Ribeiro, Carlos F.; Fernandes, RosaCancer stands as the second leading global cause of death, following heart disease. Considering the severe side effects revealed by some chemotherapeutics for tumor treatment and anticancer therapies, the scientific community is actively exploring more effective alternatives. Photodynamic Therapy (PDT) mediated by porphyrin-based photosensitizers (PS) has emerged as an attractive alternative to more conventiona...
Is silver a precious metal for G-Quadruplex stabilization mediated by porphyrins?
Moura, Nuno M. M.; Guedes, Sofia; Salvador, Diana; Oliveira, Helena; Neves, M. Graça P. M. S.; Ramos, Catarina I. V.Cancer is a leading cause of death, so continuous efforts into cancer therapy are imperative. In tumor cells, telomerase and oncogene activity are key points for uncontrolled cell growth. Targeting these processes with ligands that inhibit telomerase and/or reduce oncogene expression has been identified as a promising cancer therapy. This study evaluated the selectivity and affinity of the silverII complex of 5...
Starch-based films doped with porphyrinoid photosensitizers for active skin wou...
Lopes, Paloma; Joaquinito, A. Sofia M.; Ribeiro, Artur; Moura, Nuno M. M.; Gomes, Ana T. P.; Guerreiro, Susana G.; Faustino, M. Amparo F.Starch is a biodegradable and biocompatible carbohydrate that, when combined with bioactive molecules, can be processed as biomimetic platforms with enhanced performance, allowing its use as active wound dressing materials. Porphyrinoid photosensitizers can tune the physicochemical/functional profile of biomacromolecules, allowing their use in anti-infective strategies. In this work, the feasibility of using th...
Development of catalyst-free approach to synthesize novel spiro[indoline-3,1′-p...
Abdelmouna, Khalid; Laghchioua, Fatima; Almeida Paz, Filipe A.; Mendes, Ricardo F.; Moura, Nuno M. M.; Faustino, Maria A. F.; Cavaleiro, José A. S.Spiro compounds are a class of naturally occurring organic molecules with a wide broad of applications in several fields, mainly in medicinal chemistry. Spirooxindoles have been considered by the scientific community as scaffolds for applications under medicinal purposes, namely as anticancer, antiviral, or antimicrobial agents. Due to this fact, the synthesis of spirocompounds, namely spirooxindoles is a hot t...
Starch-based films doped with porphyrinoid photosensitizers for active skin wou...
Lopes, Paloma; Joaquinito, A. Sofia M.; Ribeiro, Artur; Moura, Nuno M. M.; Gomes, Ana T. P.; Guerreiro, Susana G.; Faustino, M. Amparo F.Starch is a biodegradable and biocompatible carbohydrate that, when combined with bioactive molecules, can be processed as biomimetic platforms with enhanced performance, allowing its use as active wound dressing materials. Porphyrinoid photosensitizers can tune the physicochemical/functional profile of biomacromolecules, allowing their use in anti-infective strategies. In this work, the feasibility of using th...
Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosens...
Gomes, Ana T. P. C.; Neves, M. Graça P. M. S.; Fernandes, Rosa; Ribeiro, Carlos F. M.; Cavaleiro, José A. S.; Moura, Nuno M. M.In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2'-bipyridine)dichloroplatinum(II) and of the analogs' derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to gener...
Graphene oxide and graphene quantum dots as delivery systems of cationic porphy...
Menilli, Luca; Monteiro, Ana R.; Lazzarotto, Silvia; Morais, Filipe M. P.; Gomes, Ana T. P. C.; Moura, Nuno M. M.; Fateixa, Sara; Faustino, Maria A. F.The development of new photodynamic therapy (PDT) agents designed for bladder cancer (BC) treatments is of utmost importance to prevent its recurrence and progression towards more invasive forms. Here, three different porphyrinic photosensitizers (PS) (TMPyP, Zn-TMPyP, and P1-C5 ) were non-covalently loaded onto graphene oxide (GO) or graphene quantum dots (GQDs) in a one-step process. The cytotoxic effects of ...
Unraveling the photodynamic activity of cationic benzoporphyrin-based photosens...
Gomes, Ana T. P. C.; Neves, M. Graça P. M. S.; Fernandes, Rosa; Ribeiro, Carlos F.; Cavaleiro, José A. S.; Moura, Nuno M. M.In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to gener...
Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphy...
Menilli, Luca; Monteiro, Ana Rita; Lazzarotto, Silvia; Morais, Filipe M. P.; Gomes, Ana T. P. C.; Moura, Nuno M. M.; Fateixa, SaraThe development of new photodynamic therapy (PDT) agents designed for bladder cancer (BC) treatments is of utmost importance to prevent its recurrence and progression towards more invasive forms. Here, three different porphyrinic photosensitizers (PS) (TMPyP, Zn-TMPyP, and P1-C5) were non-covalently loaded onto graphene oxide (GO) or graphene quantum dots (GQDs) in a one-step process. The cytotoxic effects of t...