25 documents found, page 1 of 3
Comparative study of e-cigarette aerosol and cigarette smoke effect on ex vivo ...
Silva-Ribeiro, Tiago; Coelho, Eduardo João Louro; Genisheva, Zlatina; Oliveira, José Maria; Correia-Pinto, Jorge; Sampaio, Paula; Moura, Rute S.Electronic cigarette usage has significantly expanded among young people and pregnant women in the last decade. Although there are already some data regarding the short- and long-term consequences of e-cigarettes on human health, their effect on embryo and lung development still needs to be fully disclosed. In this sense, this study describes, for the first time, the impact of electronic cigarette aerosol on ea...
Developmental pathways underlying lung development and congenital lung disorders
Caldeira, Inês; Silva, Hugo Miguel Fernandes; Costa, Daniela Machado; Correia-Pinto, Jorge; Moura, Rute S.Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a fully functional organ. Conversely, failure to correctly regulate this intricate series of events results in severe abnormalities that may compromise postnatal s...
Retinoic acid as a modulator of proximal-distal patterning and branching morpho...
Moura, Rute S.Retinoic acid modulates numerous cellular events, namely, proliferation, differentiation, apoptosis, and patterning, hence influencing both embryo development and adult homeostasis. In vitro explant culture is a valuable technique for studying the impact of growth factors and signaling molecules, such as retinoic acid, in organ development since tissue architecture is maintained. This technique allows controlle...
Electronic cigarette aerosol: impact on embryonic lung morphology
Silva-Ribeiro, Tiago; Coelho, Eduardo; Genisheva, Zlatina; Oliveira, José Maria; Carvalho, Pedro; Correia-Pinto, Jorge; Sampaio, Paula; Moura, Rute S.Introduction: Smoking is a major public health problem responsible for 700000 deaths/year in Europe. Conventional cigarettes (c-cig) exacerbates several health issues, such as chronic obstructive pulmonary disease, fibrosis and cancer. Tobacco use during pregnancy has serious consequences to infants, since they become more susceptible to develop congenital disorders, lung diseases and sudden death. Electronic c...
STATs in lung development: distinct early and late expression, growth modulatio...
Piairo, Paulina C.; Moura, Rute S.; Baptista, Maria João Ribeiro Leite; Correia-Pinto, Jorge; Silva, Cristina Isabel NogueiraCongenital diaphragmatic hernia (CDH) is a life-threatening developmental anomaly, intrinsically combining severe pulmonary hypoplasia and hypertension. During development, signal transducers and activators of transcription (STAT) are utilized to elicit cell growth, differentiation, and survival.Background: Congenital diaphragmatic hernia (CDH) is a life-threatening developmental anomaly, intrinsically combinin...
Molecular Aspects of Avian Lung Development
Moura, Rute S.; Correia-Pinto, JorgeThe pulmonary system develops from a series of complex events that involve coordinated growth and differentiation of distinct cellular compartments. After lung specification of the anterior foregut endoderm, branching morphogenesis occurs generating an intricate arrangement of airways. This process depends on epithelial-mesenchymal interactions tightly controlled by a network of conserved signaling pathways. Th...
Serotonin regulates prostate growth through androgen receptor modulation
Dias, Emanuel Carvalho; Miranda, Alice; Martinho, Olga; Mota, Paulo; Costa, Ângela Margarida Amorim; Nogueira-Silva, Cristina; Moura, Rute S.Aging and testosterone almost inexorably cause benign prostatic hyperplasia (BPH) in Human males. However, etiology of BPH is largely unknown. Serotonin (5-HT) is produced by neuroendocrine prostatic cells and presents in high concentration in normal prostatic transition zone, but its function in prostate physiology is unknown. Previous evidence demonstrated that neuroendocrine cells and 5-HT are decreased in B...
Canonical sonic Hedgehog signaling in early lung development
Silva, Hugo Miguel Fernandes; Correia-Pinto, Jorge; Moura, Rute S.The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, it is able to trigger tissue-specific responses that, ultimately, contribute to the formation of a fully functional organism. Of all three HH proteins, Sonic ...
Retinoic acid regulates avian lung branching through a molecular network
Silva, Hugo Fernandes; Cunha, Patrícia Vaz; Barbosa, Violina Baranauskaite; Gonçalves, Carla Silva; Pinto, Jorge Correia; Moura, Rute S.Retinoic acid (RA) is of major importance during vertebrate embryonic development and its levels need to be strictly regulated otherwise congenital malformations will develop. Through the action of specific nuclear receptors, named RAR/RXR, RA regulates the expression of genes that eventually influence proliferation and tissue patterning. RA has been described as crucial for different stages of mammalian lung m...
Expression analysis of Shh signaling members in early stages of chick lung deve...
Moura, Rute S.; Gonçalves, Carla Silva; Cunha, Patrícia Vaz; Correia-Pinto, JorgeLung organogenesis is guided by epithelial-mesenchymal interactions that coordinate cellular events responsible for the formation of the respiratory system. Several signaling pathways have been implicated in this process; among them, sonic hedgehog (Shh) signaling has emerged as a crucial regulator of branching morphogenesis in the mammalian lung. Canonical Shh signaling requires the presence of patched (Ptch) ...