11 documents found, page 1 of 2
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory proce...
Miranda, Marina Barcelos de; Lanna, Mariana Ferreira; Nascimento, Ana Luiza Barros; Paula, Carmen Aparecida de; Silva, Marcelo EustáquioThe occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was t...
Trypanosoma cruzi antigens induce inflammatory angiogenesis in a mouse subcutan...
Silva, Francisca Hildemagna Guedes da; Bajracharya, Deena Shrestha; Salles, Beatriz Cristina Silveira; Figueiredo, Vivian Paulino; Lopes, Laís RoqueteAcute inflammation and angiogenesis are persistent features of several pathological conditions induced by biological agents leading to the resolution of local and systemic events. Glycoproteins derived from the protozoan Trypanosoma cruzi are suggested to mediate angiogenesis induced by inflammatory cells with still undescribed mechanisms. In this study, we investigated the effects of total antigen from trypoma...
Vasoactive intestinal peptide reduces the inflammatory profile in mice infected...
Higyno, Pulchéria Maria Silva; Mendes, Priscila Fagundes; Miranda, Marina Barcelos de; Pereira, Dario Elias; Mota, Ana Paula LucasVasoactive intestinal peptide (VIP) has gained great prominence because of its therapeutic potential, which is ascribed to its ability to regulate innate immunity, inhibit antigen-specific Th1 cell responses, and generate T regulatory cells. Additionally, VIP may act as a natural antimicrobial peptide, killing bacteria, fungi, and infective forms of Trypanosoma brucei. Despite the possible relevance of VIP duri...
Methotrexate locally released from poly (caprolactone) implants : inhibition of...
Oliveira, Leandro Gonzaga de; Figueiredo, Letícia Aparecida; Cunha, Gabriella Maria Fernandes; Oliveira, Laser Antônio Machado deIn this study, the methotrexate (MTX) was incorporated into the poly(-caprolactone) (PCL) to design implants (MTX PCL implants) aiming the local treatment of inflammatory angiogenesis diseases without causing systemic side effects. Sponges were inserted into the subcutaneous tissue of mice as a framework for fibrovascular tissue growth. After 4 days, MTX PCL implants were also introduced, and anti-inflammatory...
Desenvolvimento de modelo experimental para estudo do processo de cicatrização ...
Moura, Sandra Aparecida Lima deCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; The effect of different propolis extracts (aqueous - PA and ethanolic - PE) at the concentration of 5% was investigated in the treatment of wounds using vaseline as lanoline vehicle. The wounds were experimentally produced in 20 rabbits divided in four groups according to treatment (aqueous propolis 5%, alcoholic propolis 5%, vaseline and no treatment...
Association of liposome-encapsulated trivalent antimonial with ascorbic acid: a...
Castro, Renata Alves de Oliveira e; Barcellos, Neila Marcia Silva; Licio, Carolina Souza Andrade; Souza, Janine Braga deVisceral leishmaniasis (VL) is a chronic debilitating disease endemic in tropical and subtropical areas, caused by protozoan parasites of the genus Leishmania. Annually, it is estimated the occurrence of 0.2 to 0.4 million new cases of the disease worldwide. Considering the lack of an effective vaccine the afflicted population must rely on both, an accurate diagnosis and successful treatment to combat the disea...
Ecto-nucleotidase activities of promastigotes from leishmania (Viannia) brazili...
Leite, Pauline Martins; Gomes, Rodrigo Saar; Figueiredo, Amanda Braga de; Serafim, Tiago Donatelli; Tafuri, Wagner Luiz; Gomes, Carolina CavaliériBackground: Leishmania (Viannia) braziliensis has been associated with a broad range of clinical manifestations ranging from a simple cutaneous ulcer to destructive mucosal lesions. Factors leading to this diversity of clinical presentations are not clear, but parasite factors have lately been recognized as important in determining disease progression. Given the fact that the activity of ecto-nucleotidases corr...
Brazilian green propolis modulates inflammation, angiogenesis and fibrogenesis ...
Lima, Luiza Dias da Cunha; Andrade, Silvia Passos de; Campos, Paula Peixoto; Barcelos, Luciola da Silva; Soriani, Frederico MarianettiBackground: Chronic inflammatory processes in the peritoneal cavity develop as a result of ischemia, foreign body reaction, and trauma. Brazilian green propolis, a beeswax product, has been shown to exhibit multiple actions on inflammation and tissue repair. Our aim was to investigate the effects of this natural product on the inflammatory, angiogenic, and fibrogenic components of the peritoneal fibroproliferat...
Analysis using canine peripheral blood for establishing in vitro conditions for...
Viana, Kelvinson Fernandes; Soares, Rodrigo Dian de Oliveira Aguiar; Roatt, Bruno Mendes; Resende, Lucilene Aparecida; Lemos, Denise da SilveiraCanine visceral leishmaniasis (CVL) is a parasitic disease endemic in many countries, anddogs present as the major natural reservoir of the parasite, Leishmania chagasi (syn. L.infantum). Biomarkers in the canine immune system is an important technique in thecourse of developing vaccines and treatment strategies against CVL. New methodologiesfor studying the immune response of dogs during Leishmania infection a...
Leishmania metacyclogenesis is promoted in the absence of purines.
Serafim, Tiago Donatelli; Figueiredo, Amanda Braga de; Costa, Pedro Augusto Carvalho; Silva, Eduardo de Almeida Marques da; Gonçalves, RicardoLeishmania parasites, the causative agent of leishmaniasis, are transmitted through the bite of an infected sand fly. Leishmania parasites present two basic forms known as promastigote and amastigote which, respectively, parasitizes the vector and the mammalian hosts. Infection of the vertebrate host is dependent on the development, in the vector, of metacyclic promastigotes, however, little is known about the ...