2 documents found, page 1 of 1
MicroRNA-mediated control of mesenchymal stem/stromal cell senescence: A compar...
Giestinhas, Andrea; Moura, Sara Reis; Silva, Elsa; Nascimento, Diana; Almeida, Maria InêsOsteoarthritis is a growing health problem, aggravated by aging. Mesenchymal stem/stromal cells (MSCs) emerged as a promising cell-based therapy for this disease. However, in vitro expansion of MSCs can result in cell senescence. MicroRNAs (miRNAs) are key regulators of senescence pathways, making them attractive targets to decrease senescence. This work aims to identify senescence-related miRNAs, with the long...
A first-in-class inhibitor of homologous recombination DNA repair counteracts t...
Calheiros, Juliana; Silva, Rita; Barbosa, Filipa; Morais, João; Moura, Sara Reis; Almeida, Sofia; Fiorini, Elena; Mulhovo, Silva; Aguiar, Tatiana QuintaBackground Pancreatic ductal adenocarcinoma (PDAC) is among the cancer types with poorest prognosis and survival rates primarily due to resistance to standard-of-care therapies, including gemcitabine (GEM) and olaparib. Particularly, wild-type (wt)BRCA tumours, the most prevalent in PDAC, are more resistant to DNA-targeting agents like olaparib, restraining their clinical application. Recently, we disclosed a m...