13 documents found, page 1 of 2
Perfis serológicos atípicos no diagnóstico laboratorial da infeção pelo vírus E...
Moura, Sofia; Rio, Carla; Almeida, Laura; Figueiredo, Maria Gabriela; Cavaleiro, Luísa; Silva, Anabela SantosOs testes laboratoriais de pesquisa de anticorpos específicos para o vírus Epstein-Barr são uma das ferramentas usadas para a rápida e correta identificação da infeção causada por este vírus. No entanto, existem perfis serológicos atípicos que dificultam a obtenção de um diagnóstico. Assim, o objetivo deste estudo foi determinar a frequ ência dos perfis serológicos atípicos e caracterizar a sua distribuição em ...
Distribuição temporal e geográfica da leptospirose humana diagnosticada em indi...
Moura, Sofia; Rio, Carla; Gomes, Susana; Silva, Anabela SantosEm Portugal, a leptospirose humana é considerada uma doença de declaração obrigatória (DDO). De acordo com o relatório DDO 2013- -2016, a área geográfica de intervenção da ARS Norte é a segunda área do país com maior número de casos notificados de leptospirose em humanos. O objetivo deste estudo foi analisar a distribuição temporal e geográfica dos casos de leptospirose humana identificados em indivíduos reside...
Schistosomiasis and soil-transmitted helminthiasis preventive chemotherapy: adv...
Lemos, Manuel; Pedro, João M.; Fançony, Cláudia; Moura, Sofia; Brito, Miguel; Nery, Susana Vaz; Sousa, Carlos Pinto; Barros, HenriquePreventive chemotherapy campaigns with praziquantel and albendazole are being implemented in Angola, as a high-priority public health intervention. However, there are no published data regarding adverse events associated with these medications. In this context, we analyzed adverse events due to co-administration of praziquantel and albendazole in endemic areas of schistosomiasis and soil-transmitted helminths i...
Integrated community-based intervention for urinary schistosomiasis and soil-tr...
Lemos, Manuel; Fançony, Cláudia; Moura, Sofia; Mirante, Clara; Sousa, Pinto de; Barros, Henrique; Nery, Susana; Brito, MiguelBackground: Schistosomiasis and soil-transmitted helminths (STH) infections are major public health problems. We aimed to study the 6-mo impact of mass drug administration with praziquantel and albendazole on urinary schistosomiasis and STH. Methods: We examined children (aged 2–15 y) from one hamlet, who provided urine and feces samples at baseline (n=197), 1 mo (n=102), and 6 mo (n=92); 67 completed the proto...
PTS micelles for the delivery of hydrophobic methotrexate
Cerqueira, Patrícia; Noro, Jennifer Martins; Moura, Sofia; Guimarães, Diana; Silva, Carla; Cavaco-Paulo, Artur; Loureiro, Ana Isabel SáPolyoxyethanyl--tocopheryl sebacate (PTS) is an amphiphilic compound with self-emulsifying properties known to form micelles. In this work, we report the production of PTS micelles for the encapsulation and delivery of a hydrophobic derivative of methotrexate, MTX di-ethylated (MTX-OEt). We optimized the micelles production by testing two different techniques: auxiliary solvent and sonication. Small and homogen...
Use of plant protection products in agriculture
Moura, Sofia; Vasconcelos, Marta; Ferreira, Ana; Moreira, FernandoIntroduction: Agriculture is an activity practiced for thousands of years by humans for food production representing risks to the workers' health. These risks are present mainly due to the use of Plant Protection Products (PPP) that despite having benefits in getting food also entail disadvantages for their handlers, to consumers of food produced and also for the environment me to carry out an empirical evaluat...
Use of plant protection products in agriculture
Moura, Sofia; Vasconcelos, Marta; Ferreira, Ana; Moreira, FernandoIntroduction: Agriculture is an activity practiced for thousands of years by humans for food production representing risks to the workers' health. These risks are present mainly due to the use of Plant Protection Products (PPP) that despite having benefits in getting food also entail disadvantages for their handlers, to consumers of food produced and also for the environment me to carry out an empirical evaluat...
Variant Rett syndrome in a girl with a pericentric X-chromosome inversion leadi...
Vieira, José Pedro; Lopes, Fátima Daniela Teixeira; Fernandes, Anabela Silva; Sousa, Maria Vânia; Moura, Sofia; Sousa, Susana; Costa, Bruno M.Rett syndrome is a neurodevelopmental disorder caused by mutations in the MECP2 gene. We investigated the genetic basis of disease in a female patient with a Rett-like clinical. Karyotype analysis revealed a pericentric inversion in the X chromosome -46,X,inv(X)(p22.1q28), with breakpoints in the cytobands where the MECP2 and CDKL5 genes are located. FISH analysis revealed that the MECP2 gene is not dislocated ...
Impact of a training course on the quality of malaria diagnosis by microscopy i...
Moura, Sofia; Fançony, Cláudia; Mirante, Clara; Neves, Marcela; Bernardino, Luís; Fortes, Filomeno; Sambo, Maria do Rosário; Brito, MiguelBackground: In Angola, malaria is an endemic disease having a major impact on the economy. The WHO recommends testing for all suspected malaria cases, to avoid the presumptive treatment of this disease. In malaria endemic regions laboratory technicians must be very comfortable with microscopy, the golden standard for malaria diagnosis, to avoid the incorrect diagnosis. The improper use of medication promotes dr...
Impacto de uma formação na qualidade do diagnóstico microscópico de malária em ...
Fançony, Cláudia; Moura, Sofia; Mirante, Clara; Neves, Marcela; Bernardino, Luís; Sambo, Rosário; Brito, MiguelA malária é uma doença endémica em Angola responsável por elevada morbilidade e mortalidade, especialmente entre crianças menores de cinco anos. Uma boa performance das técnicas de diagnóstico de malária é essencial uma vez que reduz o uso irracional de antimaláricos e melhora a qualidade da vigilância epidemiológica. A microscopia é o método de diagnóstico de referência, no entanto, a qualidade dos resultados ...