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Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneo...
Bezerra-Souza, Adriana; Jesus, Jéssica A.; Laurenti, Márcia D.; Lalatsa, Aikaterini; Serrano, Dolores R.; Passero, Luiz Felipe D. [UNESP]Made available in DSpace on 2021-06-25T10:58:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; The production of ergosterol lipid involves the activity of different enzymes and is a crucial event for the Leishmania membrane homeostasis. Such enzymes can be blocked by azoles and allylamines drugs, such as the antifungal butenafine chloride. This drug was active on parasites that cause cutaneous an...
Mechanistic insights into the leishmanicidal and bactericidal activities of Bat...
Dematei, Anderson; Nunes, João B.; Moreira, Daniel C.; Jesus, Jéssica A.; Laurenti, Márcia D.; Mengarda, Ana C. A.; Vieira, Maria SilvaSnake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (Bothrops atrox). In the present work, BatxC and two synthetic analogues, BatxC(C-2.15Phe) and BatxC(C-2.14Phe)des-Phe1, were assessed f...
Therapeutic effect of ursolic acid in experimental visceral leishmaniasis
Jesus, Jéssica A.; Fragoso, Thais N.; Yamamoto, Eduardo S.; Laurenti, Márcia D.; Silva, Marcelo S.; Ferreira, Aurea F.; Lago, João Henrique G.Made available in DSpace on 2018-12-11T17:08:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-04-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeuti...