2 documents found, page 1 of 1
Electrochemical study, on mercury, of a Meta-nitroarylamine derivative of nor-β...
Souza,Antonio A. de; Moura,Maria Aline B. F. de; Abreu,Fabiane C. de; Goulart,Marília O. F.; Silva Jr.,Eufrânio N. da; Pinto,Antonio V.The electrochemistry of 2,2-dimethyl-(3H)-3-(N-3'-nitrophenylamino)naphtho[1,2- b]furan-4,5-dione ([Q]-PhNO2), on mercury was investigated. The first peak is consistent with a quasi-reversible one-electron reduction of the ortho-quinone, forming [Q-]-PhNO2, while the second one, bielectronic, corresponds to the simultaneous reduction of the latter radical to a dianion and the nitro group to a nitro radical ani...
Cytotoxic, trypanocidal activities and physicochemical parameters of nor-²-lapa...
Silva Júnior,Eufrânio N. da; Moura,Maria Aline B. F. de; Pinto,Antonio V.; Pinto,Maria do Carmo F. R.; Souza,Maria Cecília B. V. de; Araújo,Ana J.The cytotoxicities of five nor-²-lapachone-based 1,2,3-triazoles and the precursor azidonaphthoquinone were assayed against six neoplasic cancer cell lines: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (melanoma), HL-60 (leukaemia), PC-3 (prostate) and B-16 (murine melanoma). IC50 values ranging from 0.43 to 9.48 µM were obtained. 3-(4-(1-hydroxycyclohexyl)-1H-1,2,3-triazol-1yl)-2,2-dimethylnaphtho...