2 documents found, page 1 of 1
The AHR: from a xenobiotic sensor to a Pattern Recognition Receptor, playing a ...
Moura-Alves, P.Background: The interaction between a bacterial pathogen and its host can be viewed as an “arms race” in which each participant continuously responds to the evolving strategies of the other partner. A mechanism allowing bacteria to rapidly adapt to such changing circumstances is provided by density-dependent cell-to-cell communication known as Quorum Sensing (QS). QS involves a hierarchy of signalling molecules...
T(AHR)getting the AHR: mapping the road of a xenobiotic sensor, from disease to...
Castro-Almeida, I.; Janowska, A.; Saitch, R.; Lian, Y.; Delgado, A.; Protze , J.; Moura-Alves, P.Background: The aryl hydrocarbon receptor (AHR) is a highly conserved ligand-dependent transcription factor, which recently gained recognition, beyond its role as a toxicity sensor, as a major player in different biological circumstances [1]. Our group and others have shown that AHR modulation in different scenarios, including by therapeutic drugs, impacts disease outcomes and treatment efficacy, in conditions ...