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Mechanisms of vertebrate embryo segmentation: Common themes in trunk and limb d...
Sheeba, C.J.; Andrade, Raquel P.; Palmeirim, IsabelVarious ultradian rhythms ensure proper temporal regulations during embryo development. The embryo molecular clock, which was first identified in the presomitic mesoderm (PSM) underlying periodic somite formation, is one among them. Somites are the earliest manifestation of the segmented vertebrate body and they are formed with strict temporal precision. The tetrapod limb is also a segmented structure and the f...
Getting a handle on embryo limb development: Molecular interactions driving lim...
Sheeba, C.J.; Andrade, Raquel P.; Palmeirim, IsabelDevelopment of the vertebrate embryo involves multiple segmentation processes to generate a functional, articulated organism. Cell proliferation, differentiation and patterning involve spatially and temporally regulated gene expression and signal transduction mechanisms. The developing vertebrate limb is an excellent model to study such fine-tuned regulations, whereby cells proliferate and are differentially sc...