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Structural and functional alterations in the retrosplenial cortex following neu...

Barrière, David André; Hamieh, Al Mahdy; Magalhães, Ricardo José Silva; Traoré, Amidou; Barbier, Julie; Bonny, Jean-Marie; Ardid, Denis

Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-lasting mechanical and thermal allodynia/hyperalgesia but also pain-associated comorbidities, we ...


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