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Therapeutic properties of VO(dmpp)2 as assessed by in vitro and in vivo studies...
Domingues, N.; Pelletier, J.; Ostenson, C.-G.; Castro, M. M. C. A.The bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV), VO(dmpp)2, has shown anti-diabetic effects by in vitro studies in Wistar (W) rat adipocytes and in vivo in obese Zucker rats. The aim of this work is to confirm the therapeutic properties of VO(dmpp)2 in non-obese type 2 diabetic Goto-Kakizaki (GK) rats. An in vivo study was carried out, treating W and GK rats during 21 days with a daily dose of V...
Date: 2014
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Origin: Estudo Geral - Universidade de Coimbra