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An overview on immunogenic cell death in cancer biology and therapy
Rodrigues, Mosar Corrêa; Morais, José Athayde Vasconcelos; Ganassin, Rayane; Oliveira, Giulia Rosa Tavares; Costa, Fabiana ChagasImmunogenic cell death (ICD) is a modality of regulated cell death that is sufficient to promote an adaptive immune response against antigens of the dying cell in an immunocompetent host. An important characteristic of ICD is the release and exposure of damage-associated molecular patterns, which are potent endogenous immune adjuvants. As the induction of ICD can be achieved with conventional cytotoxic agents, ...
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxici...
Ganassin, Rayane; Da Silva, Victor Carlos Mello; Araujo, Victor Hugo Sousa; Tavares, Giulia Rosa; Da Silva, Patrícia Bento; Cáceres-Vélez, Paolin RocioMade available in DSpace on 2022-05-01T13:41:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01; Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN...
Oral delivery of fish oil in oil-in-water nanoemulsion : development, colloidal...
Santos, Débora S.; Morais, José Athayde Vasconcelos; Vanderlei, Ísis A. C.; Santos, Alexandre S.; Azevedo, Ricardo Bentes de; Muehlmann, Luis AlexandreTo improve the oral absorption of fish oil and test its anti-inflammatory effect, a fish oil nanoemulsion was developed using cis-4,7,10,13,16,19-docosahexaenoic fatty acid as a biomarker for oral administration. The colloidal stability tests of the fish oil nanoemulsion showed an average size of 155.44 nm ± 6.46 (4 °C); 163.04 nm ± 9.97 (25 °C) and polydispersity index 0.22 ± 0.02 (4 °C), 0.21 ± 0.02 (25 °C), ...
Cloreto de alumínio-ftalocianina associado a nanopartículas de poli (vinil,meti...
Muehlmann, Luis AlexandreTese (Doutorado)—Universidade de Brasília, Faculdade de Ciências da Saúde, 2011.; A terapia fotodinâmica tem se apresentado como uma alternativa segura e altamente eficaz ao tratamento de diversos tipos de câncer. A sua alta eficácia decorre da indução direta de morte das células neoplásicas, da destruição da microvasculatura tumoral e do reforço da imunidade antitumoral. Todos estes efeitos derivam do estresse...
The influence of NLC composition on curcumin loading under a physicochemical pe...
Sousa Araujo, Victor Hugo; Silva, Patricia Bento da; Szlachetka, Isis Oliveira; Silva, Sebastiao William da; Fonseca-Santos, BrunoMade available in DSpace on 2020-12-12T00:07:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-05; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); The use of (nanostructured lipid carries) NLC to disperse curcumin in aqueous media is widely found in literature. However, few studies systematically analyze the influence of the lipid matrix composition and the presence of curcumin o...
Suplementaçao da dieta com lecitina de soja aumenta a produçao de lipídios com ...
Muehlmann, Luis AlexandreOrientadora: Anita Nishiyama; Dissertaçao (mestrado) - Universidade Federal do Paraná, Setor de Ciencias Biológicas, Programa de Pós-Graduaçao em Biologia Celular e Molecular. Defesa: Curitiba, 2008; Inclui bibliografia e teses; A asma é uma doença alérgica caracterizada por inflamação pulmonar induzida pela exposição a aero-alérgeno(s), o que leva à obstrução da vias aéreas. Essa doença pode incapacitar o indi...
Liposomal photosensitizers : potential platforms for anticancer photodynamic th...
Muehlmann, Luis Alexandre; Joanitti, Graziella Anselmo; Silva, Jaqueline Rodrigues da; Longo, João Paulo Figueiró; Azevedo, Ricardo Bentes dePhotodynamic therapy is a well-established and clinically approved treatment for several types of cancer. Antineoplastic photodynamic therapy is based on photosensitizers, i.e., drugs that absorb photons translating light energy into a chemical potential that damages tumor tissues. Despite the encouraging clinical results with the approved photosensitizers available today, the prolonged skin phototoxicity, poor...
PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenoc...
Souza, Ludmilla Regina de; Muehlmann, Luis Alexandre; Santos, Mayara Simonelly Costa dos; Ganassin, Rayane; Simón-Vázquez, RosanaBackground: Selol is an oily mixture of selenitetriacylglycerides that was obtained as a semi-synthetic compound containing selenite. Selol is effective against cancerous cells and less toxic to normal cells compared with inorganic forms of selenite. However, Selol’s hydrophobicity hinders its administration in vivo. Therefore, the present study aimed to produce a formulation of Selol nanocapsules (SPN) and to ...