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Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogen...

Catarata, Maria Joana; Medeiros, Rui; Oliveira, Maria José; Pêgo, Alice; Frade, João Gonçalo; Martins, Maria de Fátima; Cordeiro, Carlos Robalo

The renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.

Date: 2020   |   Origin: Estudo Geral - Universidade de Coimbra
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Germline genetic variants of the renin-angiotensin system, hypoxia and angiogen...

Catarata, Maria Joana; Medeiros, Rui; Oliveira, Maria José; Pêgo, Alice; Frade, João Gonçalo; Martins, Maria Fátima; Robalo Cordeiro, Carlos Robalo

Introduction: The renin–angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis. Methods: Geno...

Date: 2020   |   Origin: Repositório da Universidade de Lisboa
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