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A combined epigenome- and transcriptome-wide association study of the oral mast...

Richter, Gesa M.; Kruppa, Jochen; Munz, Matthias; Wiehe, Ricarda; Häsler, Robert; Franke, Andre; Martins, Orlando; Jockel-Schneider, Yvonne

Background: The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong environmental risk factor for the common oral inflammatory disease periodontitis and oral cancer. Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study (EWAS) that aimed to id...

Date: 2019   |   Origin: Estudo Geral - Universidade de Coimbra
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