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Size effects on antimicrobial efficiency of DBD plasma coated silver nanopartic...

Zille, Andrea; Fernandes, Margarida Maria Macedo; Francesko, Antonio; Tzanov, Tzanko Kaloyanov; Fernandes, Marta Susana Machado

This work studies the surface characteristics, the antimicrobial activity and the aging effect, of plasma pre-treated polyamide 6,6 fabrics (PA66) coated with silver nanoparticles (AgNPs), with the aim to identify the optimum size of nanosilver exhibiting antibacterial properties suitable for manufacturing of hospital textiles. The release of bactericidal Ag+ ions from the 10, 20, 40, 60 and 100 nm AgNPs-coated...


Size and aging effects on antimicrobial efficiency of silver nanoparticles coat...

Zille, Andrea; Fernandes, Margarida Maria Macedo; Francesko, Antonio; Tzanov, Tzanko Kaloyanov; Fernandes, Marta Susana Machado

Recently, renewed interest has arisen in silver nanopar@cles for biomedical devices because of their high surface energy, enhanced physicochemical and biological proper@es and extremely large surface area, which provides beAer contact with microorganisms. Atmospheric plasma is an alterna@ve and cost- compe@@ve method to wet chemical nanopar@cles deposi@on methods, avoiding the need of toxic solvents, expensive ...


Bacteria-responsive multilayer coatings comprising polycationic nanospheres for...

Francesko, Antonio; Fernandes, Margarida M.; Ivanova, Kristina; Amorim, Sara; Reis, R. L.; Pashkuleva, I.; Mendoza, Ernest; Pfeifer, Annett

This work reports on the development of infection-preventive coatings on silicone urinary catheters that contain in their structure and release on demand antibacterial polycationic nanospheres. Polycationic aminocellulose conjugate was first sonochemically processed into nanospheres to improve its antibacterial potential compared to the bulk conjugate in solution (ACSol). Afterwards the processed aminocellulose...


Size and aging effects on antimicrobial efficiency of silver nanoparticles coat...

Zille, Andrea; Fernandes, Margarida M.; Francesko, Antonio; Tzanov, Tzanko; Fernandes, Marta; Oliveira, Fernando; Almeida, Luís de

This work studies the surface characteristics, antimicrobial activity, and aging effect of plasma-pretreated polyamide 6,6 (PA66) fabrics coated with silver nanoparticles (AgNPs), aiming to identify the optimum size of nanosilver exhibiting antibacterial properties suitable for the manufacture of hospital textiles. The release of bactericidal Ag+ ions from a 10, 20, 40, 60, and 100 nm AgNPs-coated PA66 surface ...


Functional biopolymer-based matrices for modulation of chronic wound enzyme act...

Francesko, Antonio; da Costa, Diana Soares; Reis, R. L.; Pashkuleva, I.; Tzanov, Tzanko

Collagen, collagen/hyaluronic acid (HA) and collagen/HA/chitosan (CS) sponges loaded with epigallocatechin gallate (EGCG), catechin (CAT) and gallic acid (GA) were developed and evaluated as active chronic wound dressings. Their physico-mechanical properties, biostability, biocompatibility and ability to inhibit in vitro myeloperoxidase (MPO) and collagenase—major enzymes related with the persistent inflammatio...


GAGs-thiolated chitosan assemblies for chronic wounds treatment: control of enz...

Francesko, Antonio; Costa, Diana Soares da; Lisboa, P.; Reis, R. L.; Pashkuleva, I.; Tzanov, Tzanko

Multilayered polyelectrolyte coatings comprising thiolated chitosan (TC) and glycosaminoglycans (GAGs), chondroitin sulphate and hyaluronic acid, were built using a layer-by-layer approach. The surface activity of these coatings for binding and inhibition of enzymes related to chronic inflammation, such as collagenase and myeloperoxidase, was assessed. The build-up of five bi-layers of TC/GAGs onto gold surface...


Thiolated chitosan/glycosaminoglycans multilayered films : QCM-D study on the f...

Francesko, Antonio; Díaz-Blanco, Carlos; Lisboa, P.; Costa, Diana Soares da; Pashkuleva, I.; Reis, R. L.; Tzanov, Tzanko

Layer-by-layer technique is widely used to produce polyelectrolyte multilayered films for material surface functionalization. The technique simplicity coupled with the biological potential of biopolymers, e.g. polysaccharides, make such assemblies a suitable choice for many biomedical applications. In this study the formation of the films comprising of thiolated chitosan and glycosaminoglycans (GAGs) by alterna...


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