3 documents found, page 1 of 1
Recentes avanços na funcionalização seletiva de quinolinas
Ferreira,Dartagnan S. P.; Murie,Valter E.; Santos,Thiago dos; Vieira,Paulo C.; Clososki,Giuliano C.Heterocyclic compounds form an important and extensive group of organic substances. Among nitrogenous heterocyclic molecules, quinolines stand out for exhibiting attractive chemical and biological properties. These substances can be used as ligands, sensors, luminescent and agrochemical materials. In addition, quinoline-containing compounds can exhibit a wide spectrum of pharmacological properties, allowing the...
Acetaminophen Prodrug: Microwave-Assisted Synthesis and in vitro Metabolism Eva...
Murie,Valter E.; Marques,Lucas M. M.; Souza,Glória E. P.; Oliveira,Anderson R. M.; Lopes,Norberto P.; Clososki,Giuliano C.Propacetamol is an acetaminophen prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. After injection, it is completely converted by plasma esterases into N,N-diethylglycine and acetaminophen, its active metabolite whose mechanism of action is the inhibition of prostaglandin synthesis. Herein, we report an improved protocol for the synthes...
Zinc, Lithium and Magnesium Carbenoids: Chemical Properties and Relevant Applic...
Nishimura,Rodolfo H. V.; Murie,Valter E.; Soldi,Rafael A.; Lopes,João L. C.; Clososki,Giuliano C.Carbenoids are a class of highly reactive reagents that play an important role in modern organic synthesis. These species are very similar to singlet state carbenes since they have an ambiphilic character and react by a concerted mechanism allowing stereospecific transformations. Herein, we discuss these and other chemical aspects of zinc, lithium and magnesium carbenoids as well as relevant applications of the...