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Mixed methemoglobinemia, congenital and acquired
Murinello, António; Bicho, Manuel; Estrela Inácio, Rosa; Loureiro, Maria ConceiçãoThe authors present a case of acute methaemoglobinaemia of mixed aetiology - congenital and acquired. Excessive cutaneous absorption of aniline dye was the causal factor, but an associated moderate defect in cytochrome-b reductase as well as a glucose-6-phosphate dehydrogenase (G6PD) deficiency aggravated the clinicai course of the disease. Therapy with methylene blue was effective, but it cau...
Methemoglobinemia
Murinello, António; Bicho, Manuel; Estrela Inácio, Rosa; Loureiro, Maria ConceiçãoMethemoglobinemia refers to the existence of high blood concentrations of methemoglobin, resulting from the oxidation offerrous iron to ferric iron within the hemoglobin molecule. An extensive review of methemoglobinemia is done, initiaJJy focusing on physiological enzymatic mechanisms of oxidation/ reduction of hemoglobin, referring its efficacy in pathologic methemoglobinemia. Methe moglobinemia causes tissu...
Primary solitary amyloidoma of the lumbar spine
Murinello, António; Figueiredo Coelho, J.; Mendonça, Paula; Milheiro, Adelaide; Lázaro, António; Arias, Jesus; Teiga, Carlos; Simões, JoséPrimary solitary amyloidoma of the spine is an extremely rare form of localized deposits of amyloid on bone tissue and has a predilection for the thoracic region. It arises within the bone marrow of the vertebral body, causing pain and neurologic symptoms due to bone destruction with fracture and collapse, visible on imagiologic studies as osteolytic lesions usually associated with adjacent soft tissue masses. ...
Angiosarcoma of the lower limb misdiagnosed as deep thrombophlebitis – a review
Murinello, António; Fernandes, Cândida; Neta, Jorge; Árias, Jesus; Afonso, Ana; Cabral, Vitória; Germano, Nuno; Mendonça, Paula; Ribeiro, AnalisaAngiosarcomas are very rare sarcomas with vascular differentiation, high-grade malignant behaviour, early metastasis and generally bad prognosis. Early diagnosis is very important for adequate radical ablative surgery in order to obtain a better prognosis. The authors present a case of very aggressive angiosarcoma of the leg, admitted in a very advanced stage with extensive metastases, due to an initial misdiag...
Angioedema in C1 esterase inhibitor deficiency – A Review
Murinello, António; Braz, Sandra; Arranhado, EmíliaAngioedema, a rare potentially severe disease, is characterized by recurrent, circumscribed, solitary or multiple subcutaneous and mucosal swelling, involving the extremities, face, larynx and bowel wall. Bradykinin appears to be the main mediator of episodes. Angioedema is due to hereditary or acquired varieties of C1 esterase inhibitor (C1INH) deficiency, each one comprising two types. In type 1 hereditary an...
Use of antimalarial drugs in chemoprophylaxis and treatment of patients in non ...
Germano, Nuno; Mendonça, Rogélia Paula; Murinello, AntónioMalaria is the most important parasitic disease of man. About 40% of world population lives in high-risk malaria endemic areas. Nowadays In Europe malaria have small expression, with a low number of clinical cases in migrant population of endemic areas and in travelers to high-risk malaria endemic areas.This article is a bibliographic review about drug interactions of the antimalarial agents used in prophylaxis...
Idiopathic retroperitoneal fibrosis: atypical evolution
Murinello, António; Braz, Sandra; Gonçalves, AlineThe authors present a clinical report of a 68 year old woman, who had spontaneous clinical and laboratory amelioration of serious acute renal failure due to idiopathic retroperitoneal fibrosis, which was demonstrated on histologic examination of a surgical biopsy. Therapy with corticosteroids and implantation of bilateral ureteral stents were decided in view of laboratory signs of persistence of disease activit...
Isolated noncompaction of myocardium in adults
Nunes, Jorge; Bráz, Sandra; Gonçalves, Aline; Loureiro, Conceição; Galrinho, Ana; Pernadas, Conceição; Murinello, AntónioIsolated noncompaction of ventricular myocardium, or spongy myocardium, is a rare form of congenital cardiomyopathy, characterized by the presence of prominent trabeculations and deep intertrabecular recesses which communicate with the ventricular cavity. Heart failure, ventricular arrhythmias and systemic embolism are the major clinical manifestations. Although this is a congenital disorder, onset of symptoms ...
Cellulitis and deep neck abscess
Murinello, António; Murinello, Francisco; Loureiro, Mª Conceição; Gonçalves, AlineThe authors present a case of Staphylococci aureus deep neck abscess and cellulitis in a 54 year old woman, characterized by pain, fever and inflammatory signs, with only temporary benefit of symptoms with oral antibiotherapy. After institution of intravenous antibiotherapy and before a decision on surgical therapy, fast recovery was observed after spontaneous rupture of the deep neck abscess to the oropharynx....