31 documents found, page 1 of 4
Persistent Proinflammatory Cytokine Profile in the Tear Fluid of Stable Keratoc...
Gil, Pedro; Quadrado Gil, João; Cruz, Nuno; Costa, Celso; Rodrigues-Santos, Paulo; Sousa, Luana Madalena; Almeida, Jani Sofia; Fernandes, RosaPurpose: Keratoconus is traditionally classified as a noninflammatory corneal ectasia, despite growing evidence suggesting an underlying inflammatory component. This study evaluates whether patients with stable keratoconus exhibit persistent inflammatory activity in tear fluid compared to healthy controls. Methods: Cross-sectional case-control study. Keratoconus progression was evaluated using tomographic and c...
Topography-Guided Corneal Crosslinking for Keratoconus: Is It Enough to Treat t...
Cortinhal, Telmo; Gil, João; Rosa, Andreia; Quadrado, Maria João; Murta, JoaquimINTRODUCTION: Our objective is to report topographic and refractive outcomes in the first year following topography guided corneal crosslinking (TG-CXL) for keratoconus, with special focus given to the morphological changes in the superior, non-treated, corneal stroma. METHODS: Retrospective study. We included patients with progressive keratoconus who underwent TG-CXL: The epithelium was removed using photother...
Tocilizumab no Tratamento da Orbitopatia de Graves
Pereira, Pedro Nuno; Providência, Joana; Queirós, Tatiana; Ponces, Filipa; Castela, Guilherme; Murta, JoaquimIntrodução: A orbitopatia de Graves (GO) é uma doença inflamatória autoimune com tratamento desafiante e algo controverso. As opções terapêuticas na doença ativa moderada a grave podem incluir a terapêutica endovenosa com corticoides, outros imunomoduladores, radioterapia ou descompressão cirúrgica da órbita. O Clinical Activity Score (CAS) é uma escala clínica que quantifica os sinais e sintomas...
Surgical Management of Bilateral Limbal Stem Cell Deficiency
Lomelino Pinheiro, Rosa; Gil, João; Quadrado, Maria João; Murta, JoaquimAt the age of 43 years-old, a man was left with bilateral limbal stem cell deficiency after an ocular alkaline burn with lime, which resulted in corneal opacification. After multiple unsuccessful surgical attempts to restore vision, including penetrating keratoplasties and Boston keratoprosthesis, visual acuity was counting fingers in the left eye. At 73 years of age, the patient underwent another surgery in hi...
Mutational Spectrum, Ocular and Olfactory Phenotypes of CNGB1-Related RP-Olfact...
Geada, Sara; Teixeira-Marques, Francisco; Teixeira, Bruno; Carvalho, Ana Luísa; Lousan, Nuno; Saraiva, Jorge; Murta, Joaquim; Silva, RufinoCNGB1 gene mutations are a well-known cause of autosomal recessive retinitis pigmentosa (RP), which was recently associated with olfactory dysfunction. The purpose of this study was to report the molecular spectrum and the ocular and olfactory phenotypes of a multiethnic cohort with CNGB1-associated RP. A cross-sectional case series was conducted at two ophthalmic genetics referral centers. Consecutive patients...
Tear Film Mediators After Corneal Cross-Linking: Methodology Validation
Costa, Celso; Araújo, Mariana; Rosa, Andreia; Gil, João; Quadrado, Maria João; Tavares, Cristina; Costa, Esmeralda; Fernandes, Rosa; Costa, LígiaIntroduction: Currently, the gold-standard treatment of progressive keratoconus (KC) is corneal collagen cross-linking (CXL), in which riboflavin and ultraviolet-A radiation increase the corneal biomechanical rigidity, arresting progression. However, post-operatory results vary significantly among patients. Although it has been suggested that corneal thickness, cone location and patient’s age are important fact...
Cálculo de Lentes Intraoculares em Olhos com Baixo Comprimento Axial
Chaves, João Abreu; Raimundo, Miguel; Lobo, Conceição; Murta, JoaquimINTRODUÇÃO: O nosso objectivo foi avaliar comparativamente a previsão de fórmulas de terceira e nova geração (Barrett Universal II, Kane e Hill-RBF 3.0) no cálculo de lentes intraocula- res (LIO) com e sem o uso de um novo ajuste de comprimento axial (CA) na previsão dos resulta- dos refrativos de olhos com baixo CA. MÉTODOS: Estudo retrospectivo que inclui olhos com CA inferior a 22,0 mm submetidos a ...
Genetic Associations with Age-related Macular Degeneration and Genetic Risk Sco...
Farinha, Claudia; Barreto, Patrícia; Coimbra, Rita; Cachulo, Maria Luz; Melo, Joana Barbosa; Hoyng, Carel B.; Cunha-Vaz , José; Murta, JoaquimIntroduction: To date several genetic variants are known to play an important role in age-related macular degeneration(AMD). Variations in the genetic pool of different populations impact the disease prevalence, incidence and risk of progression. This report aims to determine the genetic contribution in the development of AMD in a Portuguese population from the Coimbra Eye Study (CES,NCT01298674,NCT02748824), a...
A 5-year longitudinal study of macular atrophy
Pinheiro, Rosa Lomelino; Farinha, Cláudia; Cachulo, Maria da Luz; Soares, Mário; Melo, Pedro; Murta, Joaquim; Silva, RufinoMacular atrophy (MA) is one of the late stages of age-related macular degeneration (AMD) and leads to irreversible loss of visual function. During the past years, efforts have been made towards a more detailed comprehension of the characteristics of MA, and a panel of retina specialists has recently established a new classification system to describe atrophy in the context of neovascular AMD, by the CONAN group...
Genomic Landscape and Natural History of Sector Retinitis Pigmentosa
Cortinhal, Telmo; Geada, Sara; Neves, Emmanuel; Carvalho, Ana Luísa; Saraiva, Jorge; Silva, Rufino; Murta, Joaquim; Marques, João PedroIntroduction: Sector retinitis pigmentosa (sRP) is a rare, atypical, and milder variant of rod-cone degeneration. Despite historically associated with RHO gene, the mutational spectrum of sRP is evolving with multiple causative genes recently implicated. This study aimed to characterize the genotypes, phenotypes, and natural history of a Portuguese cohort of sRP. Methods: Retrospective, observational study, c...