6 documents found, page 1 of 1
Urinary Mass Spectrometry Profiles in Age-Related Macular Degeneration
Laíns, Inês; Mendez, Kevin M; Gil, João Q.; Miller, John B; Kelly, Rachel S; Barreto, Patrícia Susana Correia Lopes; Kim, Ivana K; Vavvas, Demetrios GWe and others have shown that patients with different severity stages of age-related macular degeneration (AMD) have distinct plasma metabolomic profiles compared to controls. Urine is a biofluid that can be obtained non-invasively and, in other fields, urine metabolomics has been proposed as a feasible alternative to plasma biomarkers. However, no studies have applied urinary mass spectrometry (MS) metabolomic...
Human Plasma Metabolomics in Age-Related Macular Degeneration: Meta-Analysis of...
Laíns, Inês; Chung, Wonil; Kelly, Rachel S.; Gil, João; Marques, Marco; Barreto, Patrícia; Murta, Joaquim N.; Kim, Ivana K.; Vavvas, Demetrios G.The pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness worldwide, remains only partially understood. This has led to the current lack of accessible and reliable biofluid biomarkers for diagnosis and prognosis, and absence of treatments for dry AMD. This study aimed to assess the plasma metabolomic profiles of AMD and its severity stages with the ultimate goal of contributing to...
Peripapillary and macular morpho-vascular changes in patients with genetic or c...
Martins, Amélia; Rodrigues, Tiago; Soares, Mário; Dolan, Michael-John; Murta, Joaquim N.; Silva, Rufino; Marques, João P.Purpose: To evaluate the macular and peripapillary morpho-vascular changes in ADOA, using optical coherence tomography (OCT) and OCT angiography (OCTA). Methods: Prospectively defined, cross-sectional case-control study. Consecutive patients with a genetic or clinical diagnosis of ADOA along with age- and sex-matched controls were included. The radial peripapillary capillary (RPC) density and vessel density (VD...
Macular OCT-angiography parameters to predict the clinical stage of nonprolifer...
Rodrigues, Tiago M.; Marques, João P.; Soares, Mário; Simão, Sílvia; Melo, Pedro; Martins, Amélia; Figueira, João; Murta, Joaquim N.; Silva, RufinoBackground: To test whether a single or a composite set of macular vascular density parameters, evaluated with optical coherence tomography angiography (OCTA), are able to predict nonproliferative diabetic retinopathy (NPDR) staging according to the gold-standard ETDRS-grading scheme. Methods: Prospectively defined, cross-sectional study in which macular structural and vascular parameters of diabetic eyes with ...
Peripapillary neurovascular coupling in the early stages of diabetic retinopathy
Rodrigues, Tiago M.; Marques, João P.; Soares, Mário; Dolan, Michael-John; Melo, Pedro; Simão, Sílvia; Teles, João; Figueira, João; Murta, Joaquim N.Purpose: To study radial peripapillary capillary (RPC) density in the early stages of diabetic retinopathy (DR), using optical coherence tomography angiography. Methods: A cross-sectional evaluation of RPCs was performed using optical coherence tomography angiography (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Annular RPC density was the primary outcome. Global density and retinal nerve fiber layer thickne...
Real-World Results of Aflibercept versus Ranibizumab for the Treatment of Exuda...
Providência, Joana; Rodrigues, Tiago M; Oliveira, Mariana; Bernardes, João; Marques, João Pedro; Murta, Joaquim N.; Silva, RufinoIntravitreal injections of antivascular endothelial growth factors have been considered a milestone in the treatment of neovascular age-related macular degeneration (nAMD). However, the increasing incidence of AMD and the burden of visits and injections overcharge both the patient and the healthcare systems. Real-world solutions depend on treatment protocols aimed at optimizing the number of clinical visits whi...