4 documents found, page 1 of 1
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypano...
Elias, Paula Regina; Coelho, Gleicekelly Silva; Xavier, Viviane Flores; Sales Júnior, Policarpo Ademar; Romanha, Alvaro JoséA series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected c...
Experimental and clinical treatment of Chagas disease : a review.
Sales Júnior, Policarpo Ademar; Molina, Israel; Murta, Silvane Maria Fonseca; Sánchez Montalvá, Adrián; Salvador, Fernando; Oliveira, Rodrigo Corrêa deChagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a broad range of triatomines and mammalian species, including man. It afflicts 8 million people in Latin America, and its incidence is increasing in nonendemic countries owing to rising international immigration and nonvectorial transmission routes such as blood donation. Since the 1960s, the only drugs available for the clin...
Synthesis of 3,5-Diarylisoxazole derivatives and evaluation of in vitro trypano...
Souza, Aline Aparecida Nunes de; Xavier, Viviane F.; Coelho, Gleicekelly Silva; Sales Júnior, Policarpo Ademar; Romanha, Alvaro JoséChagas disease is included in the neglected tropical diseases list and is endemic to 21 Latin American countries. The two drugs currently available for treating Chagas disease are nifurtimox and benznidazole and both result in many significant side effects. The study describes the synthesis and biological evaluation of 3,5-disubstituted isoxazoles. Isoxazoles were obtained by reaction of flavones and hydroxylam...
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli
Stoco, Patrícia Hermes; Wagner, Glauber; Talavera-Lopez, Carlos; Gerber, Alexandra; Zaha, Arnaldo; Thompson, Claudia ElizabethUniversidade Federal de Santa Catarina. Florianopolis, SC, Brazil; Universidade Federal de Santa Catarina. Florianopolis, SC, Brazil/Universidade do Oeste de Santa Catarina. Joaçaba, SC, Brazil; Karolinska Institutet. Science for Life Laboratory. Department of Cell and Molecular Biology. Stockholm, Sweden; Laboratorio Nacional de Computação Cientıfica. Petropolis, Rio de Janeiro, Brazil; Universidade Federal do...