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Use of putative hepatoprotective agents as an adjunct to anti-TB treatment in E...

Kirakosyan, O; Reimann, M; Andersen, AB; Bjarnason, A; Bakos, Á; Dyrhol-Riise, AM; McLaughlin, AM; Nita, C; Pieridou, D; Chesov, D; Davidavičienė, EV

"Background: Anecdotal information suggests that clinical practice regarding the use of putative hepatoprotective agents in TB treatment varies across countries in the WHO European Region. Methods: Between November 2023 and May 2024, we conducted a standardised questionnaire survey on the use of putative hepatoprotective agents in patients receiving TB treatment among Tuberculosis Network European Trials Group ...


Tuberculosis incidence in foreign-born people residing in European countries in...

Vasiliu, A; Köhler, N; Altpeter, E; Ægisdóttir, TR; Amerali, M; de Oñate, WA; Bakos, Á; D'Amato, S; Cirillo, DM; van Crevel, R; Davidaviciene, E

"Background European-specific policies for tuberculosis (TB) elimination require identification of key populations that benefit from TB screening. Aim We aimed to identify groups of foreign-born individuals residing in European countries that benefit most from targeted TB prevention screening. Methods The Tuberculosis Network European Trials group collected, by cross-sectional survey, numbers of foreign-born TB...


Rifapentine access in Europe: growing concerns over key tuberculosis treatment ...

Guglielmetti, L; Günther, G; Leu, C; Cirillo, D; Duarte, R; Garcia-Basteiro, AL; Goletti, D; Jankovic, M; Kuksa, L; Maurer, FP; Méchaï, F; Tiberi, S

[No abstract available]


Clinical Management of Multidrug-Resistant Tuberculosis in 16 European Countries

Guenther, G; Leth, F; Alexandru, S; Altet, N; Avsar, K; Bang, D; Barbuta, R; Bothamley, G; Ciobanu, A; Crudu, V; Danilovits, M; Dedicoat, M; Duarte, R

Rationale: Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in Europe. Reported treatment success rates are around 50% or less, and cure rates are even lower. Objectives: To document the management and treatment outcome in patients with MDR-TB in Europe. Methods: We performed a prospective cohort study, analyzing management and treatment outcomes stratified by incidence of patients w...


Treatment outcomes of MDR-TB and HIV co-infection in Europe

Magis-Escura, C; Günther, G; Lange, C; Alexandru, S; Altet, N; Avsar, K; Bang, D; Barbuta, R; Bothamley, G; Ciobanu, A; Crudu, V; Davilovits, M


Beyond multidrug-resistant tuberculosis in Europe: a TBNET study

Günther, G; van Leth, F; Altet, N; Dedicoat, M; Duarte, R; Gualano, G; Kunst, H; Muylle, I; Spinu, V; Tiberi, S; Viiklepp, P; Lange, C

The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe. We evaluated second-line drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrug-resistant, pre-extensively drug-resistant (pre-XDR-TB) and XDR-TB at 23 TBNET sites in 16 European countries. Over 30% of bacilli from patients with pre-XDR-TB showed resistance to any fluoroquinolone an...


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