12 documents found, page 1 of 2
The impact of long noncoding RNAs in tissue regeneration and senescence
Silva, Júlia Tavares e; Pessoa, João; Nóbrega-Pereira, Sandrina; Jesus, Bruno Bernardes deOvercoming senescence with tissue engineering has a promising impact on multiple diseases. Here, we provide an overview of recent studies in which cellular senescence was inhibited through the up/downregulation of specific lncRNAs. This approach prevented senescence in the bones, joints, nervous system, heart, and blood vessels, with a potential impact on regeneration and the prevention of osteoarthritis and os...
NORAD-regulated signaling pathways in breast cancer progression
Capela, Ana Maria; Tavares-Marcos, Carlota; Estima-Arede, Hugo F.; Nóbrega-Pereira, Sandrina; Jesus, Bruno Bernardes deLong non-coding RNA activated by DNA damage (NORAD) has recently been associated with pathologic mechanisms underlying cancer progression. Due to NORAD's extended range of interacting partners, there has been contradictory data on its oncogenic or tumor suppressor roles in BC. This review will summarize the function of NORAD in different BC subtypes and how NORAD impacts crucial signaling pathways in this patho...
Senescent cell-derived vaccines: a new concept towards an immune response again...
Pessoa, João; Nóbrega-Pereira, Sandrina; Jesus, Bruno Bernardes deTwo recent seminal works have untangled the intricate role of tumor-associated senescent cells in cancer progression, or regression, by guiding our immune system against cancer cells. The characterization of these unique, yet diverse cell populations, should be considered, particularly when contemplating the use of senolytics, which are drugs that selectively eliminate senescent cells, in a cancer framework. He...
Age-associated metabolic and epigenetic barriers during direct reprogramming of...
Santos, Francisco; Correia, Magda; Dias, Rafaela; Bola, Bárbara; Noberini, Roberta; Ferreira, Rita S.; Trigo, Diogo; Domingues, Pedro; Teixeira, JoséHeart disease is the leading cause of mortality in developed countries, and novel regenerative procedures are warranted. Direct cardiac conversion (DCC) of adult fibroblasts can create induced cardiomyocytes (iCMs) for gene and cell-based heart therapy, and in addition to holding great promise, still lacks effectiveness as metabolic and age-associated barriers remain elusive. Here, by employing MGT (Mef2c, Gata...
Mitochondrial metabolism drives low-density lipoprotein-induced breast cancer c...
Nóbrega-Pereira, Sandrina; Santos, Francisco; Santos, Miguel Oliveira; Serafim, Teresa L.; Lopes, Ana Patrícia; Coutinho, Diogo; Carvalho, Filipa S.Most cancer-related deaths are due to metastases. Systemic factors, such as lipid-enriched environments [as low-density lipoprotein (LDL)-cholesterol], favor breast cancer, including triple-negative breast cancer (TNBC) metastasis formation. Mitochondria metabolism impacts TNBC invasive behavior but its involvement in a lipid-enriched setting is undisclosed. Here we show that LDL increases lipid droplets, induc...
Expression of NORAD correlates with breast cancer aggressiveness and protects b...
Alves-Vale, Catarina; Capela, Ana Maria; Tavares-Marcos, Carlota; Domingues-Silva, Beatriz; Pereira, Bruno; Santos, Francisco; Gomes, Carla PereiraThe recently discovered human lncRNA NORAD is induced after DNA damage in a p53-dependent manner. It plays a critical role in the maintenance of genomic stability through interaction with Pumilio proteins, limiting the repression of their target mRNAs. Therefore, NORAD inactivation causes chromosomal instability and aneuploidy, which contributes to the accumulation of genetic abnormalities and tumorigenesis. NO...
Mitochondria dysfunction and impaired response to oxidative stress promotes pro...
Trigo, Diogo; Nadais, André; Carvalho, Ana; Morgado, Bárbara; Santos, Francisco; Nóbrega-Pereira, Sandrina; da Cruz E Silva, Odete A. B.The plastic architecture of the mitochondrial network and its dynamic structure play crucial roles ensuring that varying energetic demands are rapidly met. Given the brain's high energy demand, mitochondria play a particularly critical role in neuronal and axonal energy homeostasis. With ageing physiological properties of the organism deteriorate, and are associated with loss of cellular homeostasis, accumulati...
Non-coding antisense transcripts: fine regulation of gene expression in cancer
Santos, Francisco; Capela, Ana Maria; Mateus, Francisca; Nóbrega-Pereira, Sandrina; Jesus, Bruno Bernardes deNatural antisense transcripts (NATs) are coding or non-coding RNA sequences transcribed on the opposite direction from the same genomic locus. NATs are widely distributed throughout the human genome and seem to play crucial roles in physiological and pathological processes, through newly described and targeted mechanisms. NATs represent the intricate complexity of the genome organization and constitute another ...
Metabolic determinants in cardiomyocyte function and heart regenerative strategies
Correia, Magda; Santos, Francisco; Ferreira, Rita da Silva; Ferreira, Rita; Jesus, Bruno Bernardes de; Nóbrega-Pereira, SandrinaHeart disease is the leading cause of mortality in developed countries. The associated pathology is characterized by a loss of cardiomyocytes that leads, eventually, to heart failure. In this context, several cardiac regenerative strategies have been developed, but they still lack clinical effectiveness. The mammalian neonatal heart is capable of substantial regeneration following injury, but this capacity is l...
Age-related pathways in cardiac regeneration : a role for lncRNAs?
Santos, Francisco; Correia, Magda; Nóbrega-Pereira, Sandrina; Bernardes de Jesus, BrunoAging imposes a barrier for tissue regeneration. In the heart, aging leads to a severe rearrangement of the cardiac structure and function and to a subsequent increased risk of heart failure. An intricate network of distinct pathways contributes to age-related alterations during healthy heart aging and account for a higher susceptibility of heart disease. Our understanding of the systemic aging process has alre...