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Benzocaine complexation with p-sulfonic acid calix[n]arene: experimental (1 H-N...
Arantes, Lucas M.; Varejão, Eduardo V. V.; Pelizzaro-Rocha, Karin J.; Cereda, Cíntia M. S.; Paula, Eneida de; Lourenço, Maicon P.; Duarte, Hélio A.The aim of this work was to study the interaction between the local anesthetic benzocaine and p-sulfonic acid calix[n]arenes using NMR and theoretical calculations and to assess the effects of complexation on cytotoxicity of benzocaine. The architectures of the complexes were proposed according to (1) H NMR data (Job plot, binding constants, and ROESY) indicating details on the insertion of benzocaine in the ca...
Date: 2018
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Origin: Oasisbr