7 documents found, page 1 of 1
Quality of life in breast cancer patients: the moderator role of family stress
Pereira, M. Graça; Paredes, Ana Cristina Marques; Nabiço, Rui; Ribeiro, Catarina; Ferreira, Gabriela Maria MagalhãesIn breast cancer patients, quality of life has been associated with treatment response and overall survival. One hundred women undergoing chemotherapy treatment for breast cancer completed questionnaires including demographic and clinical information, the EORTC-Quality of Life Questionnaire, Hospital Anxiety and Depression Scales, Body Image Scale, Index of Family Relations and the Life Orientation Test. The re...
Genetic variants of vascular endothelial growth factor predict risk and surviva...
Linhares, Paulo; Pereira, Marta Sofia Carvalho Ribeiro Viana; Ferreira, Mónica; Amorim, Júlia; Nabiço, Rui; Pinto, Filipe; Costa, Sandra; Vaz, RuiThe vascular endothelial growth factor regulates angiogenesis that is increased in glioma. VEGF polymorphisms are thought to modulate vascular endothelial growth factor plasma levels and therefore may be implicated in glioma risk. We aimed to clarify the role of VEGF and von Willebrand factor polymorphisms in glioma susceptibility and prognosis. A case-control study of 126 glioma patients and 180 cancer-free co...
Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in gl...
Xavier-Magalhães, Ana; Oliveira, Ana Isabel Ferreira; de Castro, Joana Vieira; Pojo, Marta; Gonçalves, Céline S.; Lourenço, TatianaAbnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas. The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor ...
Immunoglobulin genes implicated in glioma risk
Pandey, Janardan P.; Kaur, Navtej; Costa, Sandra Maria Araújo da; Amorim, Júlia; Nabiço, Rui; Linhares, Paulo; Vaz, Rui; Pereira, Marta VianaBoth genetic and environmental factors are thought to be causal in gliomagenesis. Several genes have been implicated in glioma development, but the putative role of a major immunity-related gene complex member, immunoglobulin heavy chain ? (IGHG) has not been evaluated. Prior observations that IGHG-encoded ? marker (GM) allotypes exhibit differential sensitivity to an immunoevasion strategy of cytomegalovirus, ...
Impact of EGFR genetic variants on glioma risk and patient outcome
Costa, Bruno Marques; Pereira, Marta Viana; Fernandes, Ricardo; Costa, S.; Linhares, Paulo; Vaz, Rui; Pinheiro, Céline; Lima, Jorge; Soares, PaulaBACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, -216G/T and -191C/A, and a polymorphic (CA)(n) microsatellite sequence in intron 1. We aimed to elucidate the...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, Bruno Marques; Caeiro, Cláudia; Guimarães, Inês; Martinho, Olga; Jaraquemada, Teresa; Augusto, Isabel; Castro, Lígia; Osório, LígiaGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...
Variação do peso de doentes oncológicos em quimioterapia
Martins, Marisa; Neves, Patrícia; Coelho, Sónia; Caldas, Valéria; Nabiço, Rui; Almeida-de-Souza, JulianaIntrodução: O cancro representa 13% da mortalidade mundial e em Portugal diagnosticam-se, anualmente, entre 40 a 45 mil novos casos de cancro. A quimioterapia é largamente utilizada como terapia do cancro, um estado nutricional adequado pode reduzir complicações do tratamento. Muitos autores estudaram a alteração do peso induzida pela quimioterapia mas, enquanto que alguns mencionam que ocorre um aumento do pes...