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The influence of polysaccharide coating on the physicochemical parameters and c...
Andreani, Tatiana; Fangueiro, Joana F.; Severino, Patrícia; Souza, Ana Luiza R. de; Martins-Gomes, Carlos; Fernandes, Paula M. V.; Calpena, Ana C.The present work reports the effect of polysaccharides (chitosan and sodium alginate) on silica nanoparticles (SiNP) for hydrophilic molecules delivery taking insulin as model drug. The influence of tetraethyl orthosilicate (TEOS) and homogenization speed on SiNP properties was assessed by a 22 factorial design achieving as optimal parameters: 0.43 mol/L of TEOS and homogenization speed of 5000 rpm. SiNP mean p...
Surface engineering of silica nanoparticles for oral insulin delivery: characte...
Andreani, Tatiana; Kiill, Charlene P.; Souza, Ana Luiza R. de; Fangueiro, Joana F.; Fernandes, Lisete; Doktorovová, Slavomira; Santos, Dario L.The present work aimed at studying the interaction between insulin and SiNP surfaced with mucoadhesive polymers (chitosan, sodium alginate or polyethylene glycol) and the evaluation of their biocompatibility with HepG2 and Caco-2 cell lines, which mimic in vivo the target of insulin-loaded nanoparticles upon oral administration. Thus, a systematic physicochemical study of the surface-modified insulin-silica nan...
The GLP-1 system: biochemistry physiological effects and the role of DDP-IV inh...
Andreani, Tatiana; Silva, Amélia M.; Souza, Ana Luiza R. deType-2 diabetes mellitus (T2DM) is a metabolic disease characterized mainly by hyperglycemia, resulting from defects in β-cell function and/or insulin resistance. Treatment approaches include diet, exercise, and pharmacological agents these however can produce adverse effects such as weight gain and hypoglycemia. Glucagon-like peptide-1 (GLP-1) is a peptide hormone that controls glycaemia and preserves β-cell m...