2 documents found, page 1 of 1
Valproic acid neuroprotection in the 6-OHDA model of Parkinson’s disease is pos...
Ximenes, José Christian Machado; Neves, Kelly Rose Tavares; Leal, Luzia Kalyne Almeida Moreira; Carmo, Marta Regina Santos doParkinson’s disease is a neurodegenerative disorder where the main hallmark is the dopaminergic neuronal loss. Besides motor symptoms, PDalso causes cognitive decline. Although current therapies focus on the restoration of dopamine levels in the striatum, prevention or disease-modifying therapies are urgently needed. Valproic acid (VA) is a wide spectrum antiepileptic drug, exerting many biochemical and physiol...
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms
Cruz, Giovany Michely Pinto da; Felipe, Cícero Francisco Bezerra; Scorza, Fúlvio Alexandre; Costa, Marta Aline Coelho da; Tavares, Alinne FariasPiperine, an alkaloid present in the Piper genus, was shown to have an anticonvulsant activity, evaluated by the pilocarpine-induced model, in mice. Pilocarpine (350 mg/kg, i.p.) was administered 30 min after piperine (2.5, 5, 10 and 20 mg/kg, i.p.) which significantly increased latencies to 1st convulsion and to death, and percentage of survivals. These parameters were also increased in the pilocarpine groups ...