Made available in DSpace on 2019-10-06T15:56:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Methylation patterns established and maintained at CpG sites may be altered by single nucleotide polymorphisms (SNPs) within these sites and may affect the regulation of nearby genes. Our aims were to: 1) identify and generate a database of SNPs potentially subject to epigenetic control by DNA methylati...
Made available in DSpace on 2019-10-06T16:08:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); β-thalassemia is a worldwide distributed monogenic red cell disorder, characterized by an absent or reduced beta globin chain synthesis. The unbalance of alpha-gamma chain and the presence of pathological free iron promote severe oxidative d...