13 documents found, page 1 of 2
Efeito da revacinação com bcg na detecção de anticorpos ANTI-PGL1 em contatos m...
Aguiar, Edglesy Carneiro; Pinto, Luiz Carlos Albuquerque; Macedo, Alexandre Casimiro de; Nagao-Dias, Aparecida Tiemi; Câmara, Lília Maria CarneiroA vacina BCG é ministrada ao nascer como imunoprofilaxia contra a tuberculose, sendo indicada a revacinação aos contatos de hanseníase, sem sinais e/ou sintomas da doença, e com uma ou nenhuma cicatriz vacinal, variando, no Brasil, a proteção de 20 a 80%. O Brasil tem 96% dos casos novos de hanseníase em ≤ 15 anos das Américas, tornando a faixa etária objeto de estudos para diagnóstico precoce. A pesquisa sorol...
Antioxidant and anti-inflammatory activities of Bauhinia ungulata L. (Fabaceae)...
Rodrigues, Raphael de Oliveira; Yaochite, Juliana Navarro Ueda; Braga, Milena Aguiar; Sousa, Amanda Ribeiro de; Sasahara, Greyce LuriObjective: The present study aimed to investigate the antioxidant, immunomodulatory and antimicrobial activities of Bauhinia ungulata L. Method: A flavonoid-rich fraction was obtained from the Bauhinia ungulata L stem, called the ethyl acetate fraction of Bauhinia ungulata (FABU). The total antioxidant capacity of the FABU was determined through the phosphomolibdenium reduction method. For the evaluation of its...
Investigating true β-lactam allergy in the outpatient allergy clinics at a publ...
Francelino, Eudiana Vale; Araújo, Sarah Resende; Ferreira, Janaira Fernandes Severo; Araújo, Fabiane Milena de CastroObjective: The aim of the study was to investigate true β-lactam allergy at a public pediatric hospital. Material and Methods: Children and adolescents with allergy symptoms were referred to the Allergy and Immu-nology Service, Hospital Infantil Albert Sabin, Fortaleza, Brazil. During the allergist interviews, β-lactam drug allergy was suspected in 24 patients. Results: Urticaria, angioedema, erythematous macul...
Association of IL10 , IL4 , IFNG , and CTLA4 gene polymorphisms with efavirenz ...
Rodrigues, Raphael de Oliveira; Rabenhorst, Silvia Helena Barem; Carvalho, Paulo Germano de; Sasahara, Greyce Luri; Vasconcelos, Luciana Mabel FerreiraSUMMARY: We evaluated interleukin-10 ( IL10 ) － 592 C / A, IL4 － 589 C / T, interferon gamma ( IFNG ) ＋ 874 A / T, cytotoxic T-lymphocyte-associated antigen 4 ( CTLA4 ) ＋ 49 A / G gene polymorphisms associated with efavirenz hypersensitivity reaction. A total of 63 human immunodeficiency virus-positive patients under treatment at a public hospital were included in the study, of whom 21 presented with efavirenz ...
Serum anti- phenolic glycolipid—1 IgA correlates to IgM isotype in leprosy pati...
Macedo, Alexandre C. de; Guimarães, Juliana A.; Rodrigues, Raphael O.; Araújo, Thiago D. V.; Tavares, Clodis M.; Cabral, Paula BritoObjective: The aim of this study was to compare serum anti-phenolic glycolipid-1 IgA, IgG, and IgM levels in leprosy patients and controls. Method: Analysis of anti-PGL- 1 IgA, IgG, or IgM in serum samples from multibacillary (MB, n=32) and paucibacillary (PB, n=22) leprosy patients, and in non-endemic controls (n=17), using an indirect enzyme-linked immunosorbent assay. Results: A strong correlation between se...
Polymorphism of IL10, IL4, CTLA4, and DAO genes in cross-reactive nonsteroidal ...
Vasconcelos, Luciana Mabel Ferreira; Rodrigues, Raphael de Oliveira; Albuquerque, Andressa Almeida; Barroso, Gabrielle Dantheias; Sasahara, Greyce LuriOur aim was to evaluate genetic polymorphism of molecules involved in immunoregulatory/allergic processes in patients who presented with cutaneous hypersensitivity caused by chemically unrelated nonsteroidal anti-inflammatory drugs. Polymorphisms at IL10 (–1082 G>A), IL4 (–589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases and 97 controls by the polymerase chain reaction-restriction fr...
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium lepra...
Macedo, Alexandre Casimiro de; Cunha Júnior, José Evandro; Yaochite, Juliana Navarro Ueda; Tavares, Clodis Maria; Nagao-Dias, Aparecida TiemiConsidering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alago...
Screening of antimicrobial metabolite yeast isolates derived biome Ceará agains...
Andrade Neto, João Batista de; Silva, Cecília R. da; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia Serpa; Silva, Anderson R. daAntimicrobials benefited the history of medicine by revolutionizing the treatment of infectious diseases. However, its consequent and continuous use has led to the emergence of microorganisms which once were considered safe, but have become feared as potentially lethal pathogens (Bowler et al., 2012). Staphylococcus aureus infections are highlighted for being a major cause of systemic infections, and for being ...
Clinical and serological evolution in chronic Chagas disease patients in a 4-ye...
Andrade, Mônica Coelho; Oliveira, Maria de Fátima; Nagao-Dias, Aparecida Tiemi; Coêlho, Ivo Castelo Branco; Bezerra, Fernando Schemelzer MoraesIntroduction: The role of trypanocidal therapy in the chronic phase of Chagas disease remains controversial. Methods: A total of 13 patients with chronic Chagas disease were treated with benznidazole (5mg/kg/day/60 days) and surveyed via antibody measurement and conventional electrocardiogram over the course of 4 years. Results: The antibody titers were signifi cantly reduced after 4 years (p<0.05). Most of the...
Effect of subinihibitory and inhibitory concentrations of Plectranthus amboinic...
Gonçalves, Thially Braga; Braga, Milena Aguiar; Oliveira, Francisco F.M. de; Santiago, Gilvandete M.P.; Carvalho, Cibele B.M.; Cabral, Paula Brito eWe evaluated the antimicrobial activity and some mechanisms used by subinhibitory and inhibitory concentrations of the essential oil, obtained from leaves of Plectranthus amboinicus , against a standard strain of Klebsiella pneumoniae and 5 multiresistant clinical isolates of the bacteria. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), the rate of kill and the pH sensit...